Showing posts with label repeat traumatic brain injury. Show all posts
Showing posts with label repeat traumatic brain injury. Show all posts

Monday, December 30, 2013

NIH and NFL will research long-term effects of concussions

This article outlines research that will be done on the long-term effects and consequences of concussions. This research will be done as a partnership between the National Institutes of Health (NIH) and the National Football League (NFL).

The U.S. National Institutes of Health is teaming up with the National Football League on research into the long-term effects of repeated head injuries and improving concussion diagnosis.
The projects will be supported largely through a $30 million donation made last year to the Foundation for the National Institutes of Health by the NFL, which is wrestling with the issue of concussions and their impact on current and former players.
There's growing concern about the potential long-term effects of repeated concussions, particularly among those most at risk, including football players and other athletes and members of the military.
Current tests can't reliably diagnosis concussion. And there's no way to predict which patients will recover quickly, suffer long-term symptoms or develop a progressive brain disease called chronic traumatic encephalopathy (CTE), according to an NIH press statement released Monday.
"We need to be able to predict which patterns of injury are rapidly reversible and which are not. This program will help researchers get closer to answering some of the important questions about concussion for our youth who play sports and their parents," Story Landis, director of the National Institute of Neurological Disorders and Stroke (NINDS), said in the news release.
Two of the projects will receive $6 million each and will focus on determining the extent of long-term changes that occur in the brain years after a head injury or after numerous concussions. They will involve researchers from NINDS, the National Institute of Child Health and Human Development and academic medical centers.
One of the projects will attempt to define a clear set of criteria for various stages of CTE. It will also seek to distinguish it from Alzheimer's disease, amyotrophic lateral sclerosis (Lou Gehrig's disease) and other degenerative brain diseases that as of now can only be determined in brain tissue samples collected after death. The objective is to find medical signs of CTE that might eventually be used to diagnose the illness in living people.
The other project will seek to identify the long-term effects of mild, moderate and severe traumatic brain injury (TBI) and compare them with features of CTE. The goal is to identify signs that could be used to diagnose brain degeneration linked to traumatic brain injury in patients.
While the two projects focus on different aspects of traumatic brain injury, "their combined results promise to answer critical questions about the chronic effects of single versus repetitive injuries on the brain, how repetitive TBI (traumatic brain injury) might lead to CTE, how commonly these changes occur in an adult population, and how CTE relates to neurodegenerative disorders like Alzheimer's disease," Landis said.
Six other pilot projects will receive a total of just over $2 million and last up to two years. They will concentrate on improving the diagnosis of concussions and identifying potential medical signs that can be used to assess a patient's recovery. If the early results are promising, these projects may form the basis of more extensive research, the news release said.

Wednesday, June 26, 2013

Repeat concussions in children mean longer recovery time

A new study shows that children who receive repeat concussions take longer to recover.

Young people may take longer to recover after their second or third concussion, a new study suggests.
Researchers typically believe the average athlete needs up to two weeks to stop having symptoms - such as headaches and memory problems - after a concussion.
But in the new study, children and young adults who had just suffered their second concussion in the last year took an average of 35 days to get back to normal.
"We have to be cautious in terms of after two weeks, if you still have symptomatic athletes, that you're not trying to hurry them back," said Dr. Paul Comper, a concussion researcher from the University of Toronto.
"The most important piece of information that comes out of this study is, if you've had prior concussions, the 10- to 14-day (recovery) thing may be completely out the window," Comper, who wasn't involved in the new study, told Reuters Health.
"For you, it might be a month."
He said the findings aren't totally surprising - it's clear that multiple head injuries are a bad thing - but they give doctors more information to pass on to their young patients after a concussion.
Studies have been piling up showing the potential harms of concussions among kids (see Reuters Health story of March 4, 2012 here: http://reut.rs/yKlv85).
And the apparent suicides of Junior Seau and other professional football and hockey players, some of whose brains showed damage from multiple head injuries, have raised concerns about depression tied to repeat concussions.
The new study included 280 youth, age 11 to 22, who came to the emergency room within a few days of having a concussion. About two-thirds of them were injured playing sports, most commonly hockey, soccer, football and basketball.
After going home, kids filled out up to six questionnaires about their symptoms over the next 12 weeks, and reported the last day they had any concussion-related problems.
Of the 235 kids who completed the study, 68 had a history of concussion.
On average, participants who had never had a concussion before took 12 days to recover from their head injury. That compared to 24 days among those with at least one past concussion, and 35 days if that prior concussion had been within the last year, the study team reported Monday in Pediatrics.
That finding, the lead author said, gives parents and doctors "even more reason for caution" when deciding how long a child should be kept out of sports or school after a head injury.
"Even after symptoms have improved and even after these neuropsychological tests have returned to normal, there's still a vulnerability that can lead to a much more severe second concussion," Dr. Matthew Eisenberg, from Boston Children's Hospital, told Reuters Health.
The researchers said one limitation to their study was that they relied on kids to report when their symptoms were gone - and some may have had incentives to say they were better to return to sports, or to say they weren't to stay home from school.
Eisenberg said the next goal is to look for something on a blood test, urine test or brain scan that will tell doctors when a child is truly back to normal.
There's also a need for follow-up research on kids with concussions, he said, because what parents want to know most is whether their child will have any lingering issues years down the line.
"The big question that still needs to be answered is, what are the long-term effects of these concussions?"
Read more here

Wednesday, May 22, 2013

NIH's Information on Concussions

The following was released by the National Institutes of Health on concussions. They discussed how serious concussions are, especially repeat concussions, and gave symptoms to take notice of.


Your brain is your body’s command center. Its soft, sensitive tissues float in a cushioning fluid within the hard and sturdy skull. But a swift blow to the head or violent shaking can override these protections and lead to a mild type of brain injury known as a concussion. 
More than 1 million mild traumatic brain injuries occur nationwide each year. These injuries can be caused by falls, car crashes or recreational activities like bike riding, skateboarding, skiing or even playing at the playground. More than half of concussions occur in children—often when playing organized sports such as football and soccer. 
“Although concussions are considered to be a mild brain injury, they need to be taken seriously. They should not be treated as minor injuries that quickly resolve,” says Dr. Beth Ansel, an expert on rehabilitation research at NIH. With proper care, most people recover fully from a concussion. “But in some cases, a concussion can have a lasting effect on thinking, attention, learning and memory,” Ansel adds. 
A single concussion is also known to raise your risk for having another concussion—and a second concussion may be more severe. It’s important to learn to recognize the causes and symptoms of concussion so you can take steps to prevent or treat these head injuries.
“The skull is designed to prevent most traumas to the brain, but it doesn’t really prevent the brain from moving around inside the skull,” says Dr. Frederick Rivara, a specialist in pediatric injuries and prevention at the University of Washington in Seattle. “A concussion can arise from the brain moving either rapidly back and forth or banging against the side of the skull.” This sudden movement can stretch and damage brain tissue and trigger a chain of harmful changes within the brain that interfere with normal brain activities. 
More serious brain injuries that involve skull fracture, bleeding in the brain or swelling of the brain can be detected with X-rays or other imaging methods. But concussions can be more difficult to identify. 
“A concussion isn’t visible from the outside, and you can’t see it with standard imaging tools like MRI and CAT scans,” says Dr. Christopher Giza, a pediatric brain specialist at the University of California, Los Angeles. “Instead we look for the signs and symptoms of abnormal brain function to make a diagnosis.”
Common symptoms include nausea, headache, confusion, dizziness and memory problems. Loss of consciousness occurs in about 1 in 10 concussions. A person with a concussion might have trouble answering basic questions and move in an awkward, clumsy way. 
“Symptoms can arise quickly, or they can be delayed and appear over the next day or two,” Rivara adds.
For about 9 in 10 people with concussions, symptoms disappear within 7 to 10 days. Scientists have been working to learn more about those who take longer to recover. In one NIH-funded study, Dr. Keith Yeates of Ohio State University looked at 8- to 15-year-olds treated in an emergency room for mild traumatic brain injury.
“We found that the majority of these kids recovered quite quickly or showed no increase in symptoms at all,” Yeates says. “But a subgroup of kids, about 10% or 20%, showed a dramatic onset of symptoms after their injury and persistent symptoms that in some cases remained even 12 months after the injury.” 
Body-related symptoms, such as headache and dizziness, tended to fade fairly quickly, the researchers found. But thinking-related symptoms, including problems with memory and paying attention, tended to linger in some kids throughout the year-long study. Children who had lost consciousness or had some additional abnormality that showed up on MRI scans after the injury had an increased risk for lasting problems. 
“These kids were also more likely to have what looked like significant reductions in overall quality of life. And there was some evidence they were more likely to have academic problems than the kids without persistent symptoms,” Yeates says.
Yeates and others continue to explore ways to predict a person’s response to concussion. Much remains unknown about the underlying biology and outcomes of mild head injuries. Some NIH-funded researchers are looking at how injury and recovery processes differ in immature and adult brains. Other scientists are examining the problems that can arise from repeated injuries to the brain. 
Researchers know that immediately after a concussion, the brain is especially vulnerable to having a second, more serious injury. But it’s not clear why—or how long that vulnerable period lasts. Giza and his colleagues have found that a single mild injury reduces the brain’s use of the sugar glucose as a fuel, at least in rats. A second mild injury 24 hours later leads to an even steeper drop in glucose use and memory problems that last longer. But when the brain has several days to recover, and the use of glucose returns to normal, a second mild brain injury seems to be no worse than the first.
“The finding suggests that when you superimpose 2 injuries on top of each other, the consequences can be greater,” Giza says. The brain’s use of glucose might be a way to assess risk and recovery time. “But we don’t yet have a clear understanding of what happens in the human brain after first and second injuries,” Giza adds.  
Studies have found that the risk for a second injury is greatest in the 10 days following an initial concussion. If you suspect that someone has a concussion, make sure they stop whatever activity they’re doing, especially if they’re involved in a sport. Their brain dysfunction might not only cloud their thinking. It can also slow reaction times and affect their balance so they become more likely to have another injury. 
“If someone has symptoms of concussion, they shouldn’t try to finish the quarter or finish the game. They need to be taken out of play right away and be seen by a health care provider,” Rivara says. “The current recommendations are to avoid physical activity for a period of time until all the symptoms have resolved, and then have a gradual return to play.” 
Take steps to avoid concussions. “Wear helmets when appropriate, such as if you’re bicycling, skate-boarding or riding a horse,” says Rivara. Athletes can decrease their risk of concussion by wearing proper headgear and following the rules of good sportsmanship. Make living areas safer for seniors by removing tripping hazards such as throw rugs and clutter in walkways, and install handrails on both sides of stairways. 
“The bottom line is that we still need to determine the best ways to prevent, accurately diagnose, treat and assess outcomes after mild traumatic brain injury,” says Ansel.
While this research continues, do what you can to prevent concussions. Learn to recognize the symptoms. And make sure that people with signs of concussion stop their activities and seek medical attention.
Stop activity if you have these symptoms. Athletes should not return to play until evaluated by a health care provider. 
  • Headache or “pressure” in head
  • Nausea or vomiting
  • Balance problems or dizziness
  • Double or blurry vision
  • Sensitivity to light or noise
  • Feeling sluggish or groggy
  • Concentration or memory problems
  • Confusion
  • Feeling “down” or “not right”
  • Changes to sleep patterns
Adapted from the U.S. Centers for Disease Control and Prevention

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Sunday, January 13, 2013

Increased Vulnerability for Repeat Traumatic Brain Injury

This article discusses the poor outcomes associated with repeat traumatic brain injury in children and young adults.

Repeat traumatic brain injury affects a subgroup of the 3.5 million people who suffer head trauma each year. Even a mild repeat TBI that occurs when the brain is still recovering from an initial injury can result in poorer outcomes, especially in children and young adults. A metabolic marker that could serve as the basis for new mild TBI vulnerability guidelines is described in an article in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

In an Editorial, "The Window of Risk in Repeated Head Injury," accompanying this article, John T. Povlishock, PhD, Editor-in-Chief ofJournal of Neurotrauma and Professor, VCU Neuroscience Center, Medical College of Virginia, Richmond, states that recent studies of TBI in animal models have shown that while repeat injury can exacerbate structural, functional, metabolic, and behavioral responses, "these responses only occur when the injury is repeated within a specific time frame post-injury."
"Specifically, this window of risk is greatest when the interval between injuries is short, hours to days, while any risk for increased damage is obviated when the intervals between injuries are elongated over days to weeks," says Dr. Povlishock. It is not yet clear if these time periods of increased risk are age- or gender-specific or depend on the intensity of the initial injury.
A consistent finding following TBI in both humans and animal models is a decrease in glucose uptake by the brain. Mayumi Prins, Daya Alexander, Christopher Giza, and David Hovda, The UCLA Brain Injury Research Center, Los Angeles, CA, simulated single and repeat (after 1 or 5 days) mild TBI in rats and measured cerebral glucose metabolism. They tested the hypothesis that the rats' brains would be more vulnerable to the damaging effects of repeat TBI at 1 day post-injury, when glucose metabolism was still decreased, than at 5 days, when it had returned to normal levels.
In the article, "Repeat Mild Traumatic Brain Injury: Mechanisms of Cerebral Vulnerability," the authors propose that the duration of metabolic slowdown in the brain could serve as a valuable biomarker for how long a child might be at increased risk of repeat TBI.
Read more here