Showing posts with label environment. Show all posts
Showing posts with label environment. Show all posts

Thursday, October 23, 2014

Air pollutants linked to autism

A study finds that air pollutants, such as those from cars and trucks, may increase risk for autism development.

A researcher at the University of Wisconsin-Milwaukee (UWM) has added to a growing body of evidence that links autism to air pollutants such as those generated by cars and trucks.
Amy Kalkbrenner's study, published this week online at the journal Epidemiology, showed that pollution's impact on autism rates in North Carolina is similar to results of pollution-autism studies in California -- despite weather and climate differences between the two states.
In addition, the work of Kalkbrenner and her colleagues, building on previous studies, showed that women in the third trimester of pregnancy were more susceptible to the damaging effects of air pollution on their unborn child.
"It adds another piece supporting the hypothesis that environmental chemicals are part of the autism puzzle," says Kalkbrenner, an assistant professor in UWM's Joseph J. Zilber School of Public Health. Autism, a spectrum of disorders affecting interpersonal relations and work achievement, now affects some 1 in 68 children in the U.S.
Her research team focused on exposure to coarse and fine particulate matter, known as PM10, which arises in part from traffic-related air pollution. The study evaluated records in the two states, covering pre-conception through the first birthday for 87,000 children in North Carolina and 77,500 in California born in the mid-to-late 1990s. Key regions in each state were selected based on researchers' ability to simultaneously measure the level of particulate matter present, and know which children had autism in these regions.
Researchers used a new, more exact tool to measure the levels of particulate matter in smaller slices of time, based on pollution at the family's address during pregnancy. With this method, they were able to compare exposures during specific weeks of pregnancy. The approximately one thousand children who later developed some form of autism spectrum disorders were then compared to all other children.
Kalkbrenner says it was important to look at eastern states because of the differences in climate, seasonal weather patterns and the chemical make-up of the particulate matter that might impact brain development. "Evidence for a link between a chemical exposure and a health impact like autism is stronger when it can be shown in more than one region." The team found that the concentration of particulate matter was highest among children born in summer months in North Carolina and those born in fall and winter months in California.
Reasons for increased susceptibility in the third trimester of pregnancy are not known at this time. However, Kalkbrenner says this finding is consistent with theories that show links between autism and altered brain network development, specifically synaptic connections that are developing during the final months of pregnancy.
"We've now had three solid studies saying the same thing. The evidence is pretty compelling that something is going on with air pollution and autism," says Kalkbrenner, who adds that further study is needed to determine the neurodevelopmental impacts of specific chemical pollutants during precise developmental windows.
Read more here

Sunday, March 23, 2014

Autism and the environment

A study discusses how environmental factors may increase a person's risk of developing autism.

A large U.S. study suggests environmental pollution might be contributing to autism risk, although the specific culprit toxins remain unknown.
Researchers analyzed medical records and found a correlation between U.S. counties' autism rates and their rates of genital birth defects in boys, which could be a sign of some common environmental contributors.
However, the findings, which were reported March 13 in the journal PLoS Computational Biology, do not prove that any particular environmental exposure directly raises the risk for the developmental disorder, experts said.
There's no "smoking gun," said Alycia Halladay, senior director of environmental and clinical sciences for the advocacy group Autism Speaks.
"This study was not designed to figure out what the [environmental] factors are," said Halladay, who was not involved in the research.
Still, she said, experts believe autism arises from a combination of genetic vulnerability and any number of environmental exposures. Some suspects include infections such as flu during pregnancy, certain prescription drugs taken during pregnancy and environmental toxins.
These latest findings support the "scientific agreement that it's a mix of genes and environment," Halladay said.
The lead researcher on the study agreed. "Both genes and environment are important," said Andrey Rzhetsky, a professor of genetic medicine at the University of Chicago.
The task ahead, Rzhetsky said, is to figure out which environmental exposures matter.
Autism refers to a collection of disorders, usually diagnosed during childhood, that affect language and social skills.
For the study, Rzhetsky's team analyzed nearly 100 million U.S. health insurance claims for a county-by-county look at rates of autism and intellectual disability. They also examined rates of genital malformations in boys -- such as micropenis, undescended testicles and hypospadias (in which the urethral opening is on the underside of the penis).
Those genital malformations were used as an indicator of parents' exposure to environmental pollutants, Rzhetsky said. The exact causes of those birth defects are not clear, but some studies have suggested that certain environmental toxins -- including pesticides and lead -- might play a role, he said.
In this study, county rates of genital birth defects ranged from none to just over 2 percent. Overall, the researchers found, for every 1 percent increase in those birth defects, the rate of autism rose by close to 300 percent.
Even accounting for county demographics, a strong link existed between rates of genital defects and autism, Rzhetsky said.
But the reasons for the correlation aren't clear. Genes could play some role, Rzhetsky said, and so could environmental factors other than pollutants.
Halladay said endocrine disruptors -- chemicals found in plastics, food cans and other everyday products -- have been linked to genital birth defects. But so far, researchers haven't found a connection to autism risk.
On the other hand, some studies have found a link between high exposure to air pollution during pregnancy and an increased autism risk, Halladay said.
Researchers continue to look for the environmental players in autism, Halladay said. Autism Speaks has a program that funds research on the environmental factors -- including toxic exposures and nutrition during pregnancy -- that might affect autism risk.
Rzhetsky said he hopes his team's findings help fuel the interest in that type of research. "There is a lot of research focused on the genetics," he said. "But environment plays a big role."
But chemicals in the environment are only one potential reason autism rates vary across the United States.
Rzhetsky's team also found lower rates of autism in states where regulations require a doctor's diagnosis of autism before kids can qualify for special education.
Halladay said the finding is consistent with past studies suggesting that differences in diagnosis help explain regional differences in autism rates.
A 2012 study from the U.S. Centers for Disease Control and Prevention found that one in 88 U.S. children had an autism spectrum disorder -- up almost 25 percent from just a few years before. But the rate varied widely, from one in 47 in Utah to one in 210 in Alabama.
Experts speculated that the national increase had a lot to do with better detection, and that differences in awareness and autism services might explain the regional differences.
Read more here

Thursday, January 30, 2014

Pediatric migraines may be caused by environment

Different environmental factors, such as sleep deprivation, diet, and school, could play a role in pediatric migraines.

Environmental stressors play a large role in triggering migraines in children, according to Dr. Eric Pearlman.
"Migraine is definitely a pediatric disorder. It peaks in young adulthood, but it definitely occurs in kids," Dr. Pearlman, chair of the department of pediatrics at Mercer University in Savannah, Ga., said at the annual meeting of the American Academy of Pediatrics.
Epidemiologic data suggest that migraine occurs in 10.5% of 10- to 15-year-old children and 3% of 7-year-olds, and that headaches – possibly including migraines – occur in 4% of 3-year-olds. By about 13 years of age, the prevalence of migraines starts reaching adult levels of about 6% in males, and 18% in females.
Environmental factors such as sleep deprivation, dehydration, dietary factors, school stressors, hidden stressors (like peers), and hormonal fluctuations represent triggers that can be particularly pronounced in children, he noted.
With International Classification of Headache Disorders, third edition (ICHD-III) criteria, migraines can be differentiated from acute, acute recurrent, and chronic progressive or chronic nonprogressive headaches if a child has experienced at least five attacks lasting up to 72 hours (whether untreated or unsuccessfully treated), if nausea and/or vomiting or photophobia and phonophobia are present, and if the child has at least two of four characteristics, including unilateral location, pulsating quality, moderate to severe intensity, and a tendency to be aggravated by – or avoid – routine physical activity.
In children, photophobia and phonophobia can be inferred (if they report having to lie down in a dark, quiet room, for example), as many have difficulty describing or understanding these symptoms
Unilateral headaches are rare in children, Dr. Pearlman noted.
If a diagnosis of migraine is established, it is important to make the diagnosis known to the child, and to educate the child about the condition and treatments.
Consider providing handouts and referring to websites (such as theAmerican Headache Society or the National Headache Foundationsites), to help educate patients and to manage their expectations, as they need to understand you cannot cure their migraine, he advised.
Involving both the patient and their parents in decision making can improve compliance with treatment recommendations, he said.
Pharmacologic interventions can include nonspecific short-term therapies, migraine-specific therapies, and preventive treatment.
Nonspecific short-term therapies may include acetaminophen, nonsteroidal anti-inflammatory drugs, or combination drugs. Migraine-specific therapies include ergotamine and dihydroergotamine, and the "triptans."
Seven triptans are available, including two that are approved for use in children; rizitriptan (Maxalt) is approved for children older than age 6 years, and almitriptan (Axert) is approved for those aged 12-17 years.
Maxalt comes in both an oral and orally disintegrating form, and is available as a generic drug. Generic sumitriptan (Imitrex) also is available.
"There are good data for most of the triptans for adolescents aged 12 and older," Dr. Pearlman said.
Rescue medications for those who have an inadequate response to short-term therapy can include a combination of an analgesic like a nonsteroidal and an antiemetic, or an opiate and an antiemetic if the patient used a nonsteroidal initially. Rescue medications may be needed "because nothing is going to work 100% of the time," he said.
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Tuesday, October 22, 2013

Study: Sunny climates may reduce ADHD

A study indicates many risk factors for ADHD, and interestingly notes that sunny and warm climates may reduce the condition.

Attention-deficit/hyperactivity disorder, or ADHD, is the most common childhood psychiatric disorder. Scientists do not know what causes it, but genetics play a clear role. Other risk factors have also been identified, including premature birth, low birth weight, a mother's use of alcohol or tobacco during pregnancy, and environmental exposures to toxins like lead.
ADHD is characterized by an inability to focus, poor attention, hyperactivity, and impulsive behavior, and the normal process of brain maturation is delayed in children with ADHD. Many individuals with ADHD also report sleep-related difficulties and disorders. In fact, sleep disorder treatments and chronobiological interventions intended to restore normal circadian rhythms, including light exposure therapy, have been shown to improve ADHD symptoms.
Estimates suggest that the average worldwide prevalence of ADHD ranges from about 5 to 7%, but it also varies greatly by region. A simple visual comparison of data maps released by the U.S. Centers for Disease Control and Prevention and the U.S. Department of Energy that display ADHD prevalence rates by state and solar intensities (sunlight) across the country, respectively, reveals an interesting pattern indicative of an association. So does this mean that there could be an identifiable relationship between ADHD prevalence rates and the sunlight intensity levels of particular regions?
The accumulation of these points led Dr. Martijn Arns and his colleagues to systematically and scientifically investigate this question. They collected and analyzed multiple data-sets from the United States and 9 other countries. Reporting their findings in the current issue of Biological Psychiatry, they did find a relationship between solar intensity and ADHD prevalence.
Even after controlling for factors that are known to be associated with ADHD, both U.S. and non-U.S. regions with high sunlight intensity have a lower prevalence of ADHD, suggesting that high sunlight intensity may exert a 'protective' effect for ADHD.
To further validate their work, they also looked at this same relationship with autism and major depressive disorder diagnoses. They found that the findings were specific to ADHD, with no associations observed between the other two disorders.
"The reported association is intriguing, but it raises many questions that have no answers," commented Dr. John Krystal, Editor of Biological Psychiatry. "Do sunny climates reduce the severity or prevalence of ADHD and if so, how? Do people prone to develop ADHD tend to move away from sunny climates and if so, why?"
As with all scientific research, further work is necessary, including a prospective replication of these findings. It is also important to realize that this data reflects only an association -- not a causation -- between ADHD and solar intensity levels so worried parents should not start planning cross-country moves.
However, these findings do have significant implications, explains Dr. Arns. "From the public health perspective, manufacturers of tablets, smartphones and PCs could investigate the possibility of time-modulated color-adjustment of screens, to prevent unwanted exposure to blue light in the evening."
"These results could also point the way to prevention of a sub-group of ADHD, by increasing the exposure to natural light during the day in countries and states with low solar intensity. For example, skylight systems in classrooms and scheduling playtime in line with the biological clock could be explored further."
Read more here

Tuesday, October 08, 2013

Common migraine triggers to avoid

This article discusses seven common migraine triggers that those prone to migraines should avoid.

It’s estimated that 28 million americans suffer from migraines. Migraines are intense headaches that are often accompanied by nausea, vomiting and sensitivity to light. They don’t simply come and go; each migraine can last between four hours and three days. Most migraine sufferers know to avoid certain things like dairy, alcohol and food with excessive additives, but there are other external factors that could trigger a migraine. Here are some to watch out for.
1. Change in Routine
For some migraine sufferers, routine is key to keeping the headaches at bay.  Change in sleep patterns, work hours or even holidays can create stress and lead to migraines.
2. Stress
As mentioned above, migraines and stress are strongly linked. Some people report migraines start when stress reduces, sometimes leading to “weekend headaches” after a stressful work week.
3. The Environment 
High altitude, weather changes and humidity can all trigger migraines.
4. Computer Screens
Both the posture you take when sitting in front of a computer and the glare from the screen can lead to migraine pain. Be sure to sit comfortably to avoid muscle tension and use an anti-glare screen.
5. Lack of Food
Insufficient food is one of the main dietary triggers of migraines. Avoid missing meals or snacking on treats high in sugar. Eating small, nutritious snacks throughout the day can help control migraine attacks.
6. Hormonal Change (In Women)
Fluctuation in estrogen may cause headaches in women who suffer from migraines. These women often report an increase in migraines immediately before or during their menstrual cycle, when there is a major drop in estrogen levels.
7. Sensory Overstimulation
Bright lights, loud noises and unusual smells, including perfume and secondhand smoke can trigger migraines. 
Migraine triggers are unique to every individual, and can happen as early as 6 to 8 hours prior to a migraine attack.
Read more here

Monday, April 22, 2013

Study shows childhood obesity determined by environmental factors, not genetics

A study from the Scientific American claims that childhood obesity is largely determined by environmental factors, not genetics as other studies have claimed. JR


New evidence is confirming that the environment kids live in has a greater impact than factors such as genetics, insufficient physical activity or other elements in efforts to control child obesity. Three new studies, published in the April 8Pediatrics, land on the import of the 'nurture' side of the equation and focus on specific circumstances in children's or teen's lives that potentially contribute to unhealthy bulk.
In three decades child and adolescent obesity has tripled in the U.S., and estimates from 2010 classify more than a third of children and teens as overweight or obese. Obesity puts these kids at higher risk for type 2 diabetes, cardiovascular disease,sleep apnea, and bone or joint problems. The variables responsible are thought to range from too little exercise to too many soft drinks. Now it seems that blaming Pepsi or too little PE might neglect the bigger picture.
"We are raising our children in a world that is vastly different than it was 40 or 50 years ago," says Yoni Freedhoff, an obesity doctor and assistant professor of medicine at the University of Ottawa. "Childhood obesity is a disease of the environment. It's a natural consequence of normal kids with normal genes being raised in unhealthy, abnormal environments." The environmental factors in these studies range from the seemingly minor, such as kids' plate sizes, to bigger challenges, such as school schedules that may keep teens from getting sufficient sleep. But they are part of an even longer list: the ubiquity of fast food, changes in technology, fewer home-cooked meals, more food advertising, an explosion of low-cost processed foods and increasing sugary drink serving sizes (pdf) as well as easy access to unhealthy snacks in vending machines, at sports games and in nearly every setting children inhabit—these are just a handful of environmental factors research has linked to increasing obesity, and researchers are starting to pick apart which among them play bigger or lesser roles in making kids supersized.
Size matters in "obesogenic environments"
In one of the three new studies dishware size made a big difference. Researchers studied 42 second-graders in which the children alternately used child-size 18.4-centimeter (7.25-inch) diameter plates with 237-milliliter (8-ounce) bowls or adult-size 26-centimeter (10.25-inch) diameter plates with 473-milliliter (16-ounce) bowls. Doubling the size of the dishware, the researchers found, increased the amount of food kids served themselves in a buffet-style lunch line by an average of 90 calories. They ate about 43 percent of those extra calories, on average.
Although kids can typically adjust their energy intake by regulating their food, Temple University public health professor Jennifer Fisher says, their surroundings and options may change that equation for kids in the same way that it does in adults. "This notion that children are immune to the environment is somewhat misguided," says Fisher, who headed up the study. "To promote self-regulation, you have to constrain the environment in a way that makes the healthy choice the easy choice."
Fisher says much recent research in nutrition has focused on the "obesogenic" environments of today's society: a dietary environment offering widespread access to highly palatable foods in large portion sizes. "If we look at adult studies on dieting and weight loss, we know that the prospect of maintaining self-control in this environment is fairly grim," Fisher says. "I think most scientists believe our bodies have evolved to pretty staunchly defend hunger and prevent weight loss, and maybe are not so sensitive in preventing overconsumption."
Link between obesity and screen time
Overconsumption might be a key component in the link between obesity and screen time, too, according to another of the new studies. Although past research already had linked increased TV time to widening waistlines, this study dug deeper. Ninety-one 13- to 15-year-olds filled out diaries for TV, video games and computer use during a one-week period. About four to seven times a day the teens were paged to record what they were paying the most attention to at that particular moment, followed by activities receiving their second- and third-most attention. "Kids live in a multitasking world," says Harvard Medical School pediatrics professor David Bickham, lead author of the screen-time study. "We're trying to assess their technology use when they're using different forms of technology at once."
Bickham says three theories have been floated for the link between screen time and obesity: food advertising, unconscious eating and displacement—that is, the idea that the media use replaces physical activity. His team's findings lent more support to the first two variables and less to the third. They found video games and computer use had no impact on BMI (body mass index). Television did, but only if it was the main event. Background TV, for example, didn't matter.
"We're saying the level of attention may make a difference," Bickham says. "You have to pay attention to advertising for it to have the impact, and [food] advertising is much less common in computers and video games. In terms of unconscious eating, when you're watching TV, your hands are free and you're stimulating your senses with the TV, so concurrent eating is more likely to happen." Previous research (pdf) has found support for both these theories, such as a study earlier this year showing that neighborhoods with more food and soft drink outdoor advertising had higher rates of obesity. Freedhoff adds that even viewing commercials for fruits and vegetables has been shown to increase consumption of unhealthy foods. "Our hunger hormones have been honed after millions of years of dietary insecurity, so when we want to eat, we tend not to crave green leafy salads," he says.
Less physical activity is not the problem
The screen-time study did find that kids engaged in more physical activity had lower BMIs, but that does not mean that more exercise is keeping those teens lighter, Freedhoff says. "What we've seen for so many years is research looking at physical activity as the preventative or the curative solution for childhood obesity, but the data on physical activity as a means to set children's weight is abysmal," he says. "What this study confirmed is that screen time increases obesity consequent to calorie intake, not to a lack of physical activity. That's a crucial message that people don't understand—obesity is not a disease of inactivity."
The third new study, looking at the link between sleep duration and obesity in teens, further blunts the idea that physical activity accounts for much of the increase in kids' weight. Researchers tracked nearly 1,400 teenagers from ninth through 12th grade and found, like past studies, that less sleep translates to higher BMIs. By analyzing BMI distribution rather than using cutoff points, University of Pennsylvania postdoctoral fellow Jonathan Mitchell says his team detected much stronger sleep effects among already obese teens. The effect of each additional hour of sleep among teens in the 90th BMI percentile was twice as big as among those in the 10th percentile. Increasing sleep from 7.5 to 10 hours a day among 18-year-olds could shave four percentage points off the proportion of teens with a BMI over 25, the researchers predicted.
They also looked at the teens' physical activity levels. "If you're sleeping less, you're fatigued during the day and less likely to be active," Mitchell says. "But the link we observed was not fully explained by lower levels of physical activity." Another possibility is that being awake longer means more opportunities to eat, but Mitchell's team did not look at dietary intake. Past research has also found thatsleep deprivation might alter the body's regulation of hormones leptin and ghrelin, which control satiety and hunger. Or, the problem may not the total caloric intake but the timing of eating, Mitchell says. He noted mice studies where the nocturnal critters became obese if they ate during day and night but remained a normal weight if they only ate at night.
Regardless of the mechanism, these findings also support the notion that the entirety of kids' 21st-century environment—not their self-control or reduced physical activity—is the key culprit in the rise in obesity. "People like to make obesity a disease of blame, but the last 40 years has not seen an epidemic of our children losing willpower," Freedhoff says. "There are dozens and dozens of these environmental factors. Unless we reengineer our children's environments, we are not likely to see any changes in children's weights."
Freedhoff points to cities such as Philadelphia and New York, where modifying children's environments, especially in schools, may be responsible for recent reductions in obesity. Philadelphia removed sugary drinks from vending machines in 2004, then reduced snack food serving sizes, removed deep fryers from school cafeterias and replaced whole milk options with 1 percent and skim. Outside of school, more than 600 corner stores participate in the Food Trust initiative to stock their shelves with healthier snacks. New York has instituted new nutrition standards in schools (pdf) and daycare centers, as well as screen-time limits in day cares. The two metropolises also have some of the most comprehensive menu labeling laws in the country.
"This is a lot more complicated than ‘eat less, exercise more,'" Freedhoff says. "If weight management or childhood obesity prevention and treatment were intuitive, we'd have a lot of skinny kids running around." Freedhoff himself is developing a program for families that focuses on "redrafting" kids' and families' environments, starting with more home cooking. "Every parent would die for their child, but most won't cook for their children on a consistent basis with whole ingredients," he says.
But Freedhoff also says the problem of increasing childhood obesity cannot be tackled by parents alone. He suggests starting with changes within school boards, sports teams, PTAs and others who already care about kids. "What I'm amazed by is the constant use of fast food to pacify children and reward children—there is no event too small for candy or fast food." There are many places communities could start: making school lunches healthier, ditching vending machines and access to fast food inside schools, not celebrating sports wins at fast food joints, and ending the use of candy or fast food as rewards, such as "pizza days" and other unhealthy food-themed school events, to name a few. "People don't appreciate that parents are around children a minority of their days," he says, so it really will take a village to turn back the clock in terms of kids' environments. "If we had a time machine, it would be the world's best weight-loss program," Freedhoff says. "It's the world that has changed, not people."
Read more here



Friday, April 27, 2012

Top Ten Chemicals Suspected to Cause Autism


Perhaps this article may guide research? JR


An editorial published April 25 in the journal Environmental Health Perspectives calls for increased research to identify possible environmental causes of autism and other neurodevelopmental disorders in America's children and presents a list of ten target chemicals including which are considered highly likely to contribute to these conditions.
Philip Landrigan, MD, MSc, a leader in children's environmental health and Director of the Children's Environmental Health Center (CEHC) at Mount Sinai School of Medicine, co-authored the editorial, entitled "A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities," along with Luca Lambertini, PhD, MPH, MSc, Assistant Professor of Preventive Medicine at Mount Sinai and Linda Birnbaum, Director of the National Institute OF Environmental Health Sciences.
The editorial was published alongside four other papers -- each suggesting a link between toxic chemicals and autism. Both the editorial and the papers originated at a conference hosted by CEHC in December 2010.
The National Academy of Sciences reports that 3 percent of all neurobehavioral disorders in children, such as autism spectrum disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD), are caused by toxic exposures in the environment and that another 25 percent are caused by interactions between environmental factors and genetics. But the precise environmental causes are not yet known. While genetic research has demonstrated that ASD and certain other neurodevelopmental disorders have a strong hereditary component, many believe that environmental causes may also play a role -- and Mount Sinai is leading an effort to understand the role of these toxins in a condition that now affects between 400,000 and 600,000 of the 4 million children born in the United States each year.
"A large number of the chemicals in widest use have not undergone even minimal assessment of potential toxicity and this is of great concern," says Dr. Landrigan. "Knowledge of environmental causes of neurodevelopmental disorders is critically important because they are potentially preventable."
CEHC developed the list of ten chemicals found in consumer products that are suspected to contribute to autism and learning disabilities to guide a research strategy to discover potentially preventable environmental causes. The top ten chemicals are:
1. Lead
2. Methylmercury
3. PCBs
4. Organophosphate pesticides
5. Organochlorine pesticides
6. Endocrine disruptors
7. Automotive exhaust
8. Polycyclic aromatic hydrocarbons
9. Brominated flame retardants
10. Perfluorinated compounds
In addition to the editorial, the other four papers also call for increased research to identify the possible environmental causes of autism in America's children. The first paper, written by a team at the University of Wisconsin -- Milwaukee, found preliminary evidence linking smoking during pregnancy to Asperger's disorder and other forms of high-functioning autism. Two papers, written by researchers at the University of California -- Davis, show that PCBs disrupt early brain development. The final paper, also by a team at UC -- Davis, suggests further exploring the link between pesticide exposure and autism.
Read more here