Showing posts with label botox. Show all posts
Showing posts with label botox. Show all posts

Friday, July 11, 2014

Copay relief for those who use a botulinum toxin for a movement disorder or cerebral palsy. Xeomin is a type A BTX but not Botox

    • Co pay relief for those who use a botulinum toxin for a movement disorder or

    • cerebral palsy.

    •  Xeomin is a type A
    •  BTX but not Botox - JR
    • Link is here

    • Patient initiates the enrollment process by calling 1-888-4-XEOMIN (1-888-493-6646) or by faxing a XEOMIN® Patient Co-payment Program Application to 866-471-3005. Physician assists the patient in the enrollment process by verifying some of the required enrollment information (see Enrollment Form).
    • After the patient’s application is reviewed and the program determines that he or she satisfies the enrollment requirements for participation in the Co-pay Program, the patient will receive a XEOMIN® Patient Co-payment Program Enrollment Letter. Patient should discuss treatment plan with his or her physician.
    • Healthcare Provider administers XEOMIN® injection and submits claim for reimbursement for XEOMIN® to the patient’s insurance company according to the provider’s usual practice and procedure. The patient will pay his or her co-pay/coinsurance to the physician in an amount as determined by the patient’s insurance coverage/policy and the Provider’s usual co-payment collection practices.
    • Patient sends Explanation of Benefits (EOB) or specialty pharmacy shipment invoice to XEOMIN® Patient Co-payment Program by faxing to 866-471-3005 or mailing to The XEOMIN® Patient Co-payment Program: PO Box 4280 Gaithersburg, MD 20885-4280 within 120 days of injection date.
A Co-pay Program debit MasterCard, loaded with funds in the amount of the patient’s eligible out of pocket costs as determined by the Co-payment Program guidelines, is mailed directly to the patient’s home. To be eligible, a patient must be an appropriate patient for XEOMIN® treatment, as determined by their physician, have commercial insurance that covers XEOMIN® treatment, etc. and may include the cost of XEOMIN, associated guidance therapy, and related administration fees (“eligible costs”). Patients may use the card wherever debit MasterCards are accepted, including healthcare providers.
The program terms and conditions limit the amount of out-of-pocket costs that can be reimbursed to patients per XEOMIN® treatment.
The per treatment out-of-pocket cost limit is $500 or the amount of the patient's Co-pay/coinsurance, whichever is less. The following eligible costs associated with XEOMIN treatment will be reimbursable directly to the patient up to the above limit:
  • Any eligible costs specifically associated to the patient's deductible
  • Any co-pay specifically associated to eligible costs
  • Any coinsurance costs specifically associated to eligible costs
The following costs are not eligible and will not be reimbursable:
  • Office visit co-pays not directly associated with the Xeomin treatment
  • Facility co-pays not directly associated with the Xeomin treatment
  • Any other costs excluded by the Co-pay Program guidelines (e.g. not specifically mentioned above), which are subject to change.

Saturday, April 19, 2014

Botox helps those with depression

A study shows that depressive symptoms are improved by Botox injections.

"Study author M. Axel Wollmer, a psychiatrist at the University of Basel in Switzerland, believes the treatment “interrupts feedback from the facial musculature to the brain, which may be involved in the development and maintenance of negative emotions.” Past studies have shown that Botox impairs people's ability to identify others' feelings, and the new finding adds more evidence: the muscles of the face are instrumental for identifying and experiencing emotions, not just communicating them." JR

In the largest randomized, double-blind, placebo controlled study to date on the effect of OnabotulinumtoxinA (as known as Botox) on depression, researchers found that more than half of subjects suffering from moderate to severe depression showed a substantial improvement (greater than or equal to 50% of baseline) in their depressive symptoms as measured by the MADRS scale.
The study, conducted by Dr. Eric Finzi, MD, PhD and Dr. Norman E. Rosenthal, MD and published in the Journal of Psychiatric Research, included 74 depressed subjects injected with a single treatment of either onabotulinumtoxinA (OBA) or a placebo to the corrugator and procerus muscles between the eyebrows. Results showed that depressive symptoms (as assessed by the MADRS scale) in the OBA treatment group decreased 47 percent after six weeks, compared to 21 percent in the placebo group. This study is the first to show a significant difference in remission rate with OBA in depressed patients (27% OBA vs. 7% placebo).
Study co-author Dr. Norman E. Rosenthal, MD, Clinical Professor of Psychiatry at Georgetown Medical School, commented, "This research is groundbreaking because it offers those who suffer from depression and their doctors an entirely new approach to treating the condition -- one that doesn't conflict with any other treatments."
The study showed that Botox may help relieve depressive symptoms both as a stand-alone and an adjunctive treatment.
"This new research supports earlier facial feedback theory of Charles Darwin and William James which suggests that facial expressions influence mood," added Dr. Eric Finzi, Dermasurgeon and co-author on the paper that first reported that inhibition of frowning by facial injection of OBA could help depressed patients in a pilot study published in 2006.
Read more here

More here at scientific amaerican

Monday, December 30, 2013

How Botox can help with Cluster Headaches

This article discusses research that is currently being done to turn Botox into a treatment for cluster headaches.

Botox is best known as a facial wrinkle remover, but if all goes well with the research, someday soon it may be a treatment option for cluster headache. At least that is the hope of a team of scientists at the Norwegian University of Science and Technology (NTNU).
Why Botox?
Botox (onabotulinumtoxinA) is a neurotoxin and a drug that uses a potent poison called botulinum toxin, which is derived from the bacterium Clostridium botulinum. When it is injected into facial muscles, it paralyzes them temporarily and causes wrinkles to disappear for several months.
Similarly, injections of the toxin are used to block nerve signals that cause muscles contractions in cerebral palsy and bladder spasms, to block postsurgical pain and foot pain, and to temporarily relax eye muscles in people with strabismus (misaligned eyes). Botox also is sometimes used to treat migraine.
Cluster headache and Botox
Cluster headache pain is more severe than migraine pain and can drive patients to perform desperate acts, even suicide, to avoid it. Therefore finding effective treatments for this devastating condition, which affects an estimated 53 people per 100,000 per year, is essential.
That’s why Erling Tronvik, NTNU senior consultant and researcher, along with two colleagues, are about to undertake a study of the impact of Botox on cluster headache sufferers. This team has devised a treatment device that will allow them to shoot Botox through a hole in the nasal wall into a nerve bundle located behind the sinuses.
Clinicians will use magnetic resonance imaging (MRI) scans to accurately identify the location of the nerve bundle in each patient before treatment is initiated. According to Tronvik, this unique approach should (in theory) reduce or eliminate the flow of signals in this area for three to eight months, after which time patients would need to get another treatment.
“We designed the equipment ourselves, and Botox has never been used for this anywhere else,” noted Tronvik. Soon, 10 patients will enter the first pilot study of this treatment method.
If the results of the pilot study are positive, the team plans to enroll 30 to 40 patients who suffer with cluster headache and about 80 migraineurs as well.
Are there any side effects? Tronvik explained that use of MRI is a highly accurate way to locate the exact spot to inject the Botox. However, he also noted that if the toxin were to slightly miss the mark, patients could experience a weakened ability to chew or temporary double vision.
In the meantime, there’s some good news regarding chronic migraine. Botox has been shown to be helpful in relieving chronic migraine, as seen in the results of the PREEMPT (Research Evaluating Migraine Prophylaxis Therapy) clinical program.
In that study, nearly 70 percent of patients treated with Botox experienced at least a 50 percent reduction in the frequency of headache days. Other research has shown Botox to be effective as preventive treatment for chronic migraine and to provide a reduction in severity and intensity of pain as well as the number of days with disability.
If you suffer with cluster headache, a new effective treatment can’t come soon enough. Hopefully Botox or another option in the pipeline will prove beneficial in the near future.
Study References
Alvaro-Gonzalez LC et al. Botulinum toxin A in chronic refractory migraine: premarketing experience. Revista de Neurologia 2012 Oct 1; 55(7): 385-91
Aurora SK et al. OnabotulinumtoxinA for chronic migraine: efficacy, safety, and tolerability in patients who received all five treatment cycles in the PREEMPT clinical program. Acta Neurologica Scandinavica 2014 Jan; 129(1): 61-70
Read more here

Sunday, December 29, 2013

Botox for depression? Turn that frown upside down...

Its a randomized, placebo controlled clinical trial...Wow! JR

 2013 Dec 1. pii: S0022-3956(13)00356-7. doi: 10.1016/j.jpsychires.2013.11.006. [Epub ahead of print]

Treatment of depression with onabotulinumtoxinA: A randomized, double-blind, placebo controlled trial.

Abstract

Converging lines of evidence suggest a role for facial expressions in the pathophysiology and treatment of mood disorders. To determine the antidepressant effect of onabotulinumtoxinA (OBA) treatment of corrugator and procerus muscles in people with major depressive disorder, we conducted a double blind, randomized, placebo-controlled trial. In an outpatient clinical research center, eighty-five subjects with DSM-IV major depression were randomized to receive either OBA (29 units for females and 40 units for males) or saline injections into corrugator and procerus frown muscles (74 subjects were entered into the analysis). Subjects were rated at screening, and 3 and 6 weeks after OBA treatment. The primary outcome measure was the response rate, as defined by ≥ 50% decrease in score on the Montgomery-Asberg Depression Rating Scale (MADRS). Response rates at 6 weeks from the date of injection were 52% and 15% in the OBA and placebo groups, respectively (Chi-Square (1) = 11.2, p < 0.001, Fisher p < 0.001). The secondary outcome measure of remission rate (MADRS score of 10 or less) was 27% with OBA and 7% with placebo (Chi-square (1) = 5.1, p < 0.02, Fisher p < 0.03). Six weeks after a single treatment, MADRS scores of subjects were reduced on average by 47% in those given OBA, and by 21% in those given placebo (Mann-Whitney U, p < 0.0005). In conclusion, a single treatment with OBA to the corrugator and procerus muscles appears to induce a significant and sustained antidepressant effect in patients with major depression.

TRIAL REGISTRATION:

clinicaltrials.gov Identifier: NCT01556971.
Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Antidepressant, Clinical trial, Corrugator, Depression, Double blind, OnabotulinumtoxinA

Monday, November 11, 2013

Botox to treat extreme cluster headaches

Botox could be used to help treat extremely painful cluster headaches and migraine headaches.

"I hit myself in the head to distract myself from the pain when I have a cluster headache. The pain is indescribable hell, and in desperate moments, I have hit my head against a brick wall and hit myself in the head with a cell phone," says Hilde Vollan (34), a PhD candidate in bioinformatics at the University of Oslo.
Four years and four months ago, her life turned upside down when she started getting cluster headaches. Her life has been transformed -- once, she was an active student with many friends, but she now lives a life in the dark at home with her parents. She has two to five cluster headaches every day, and also suffers from migraine and tension headaches. If she dares to go out for a walk, she always brings someone who can support her, and a bag of pills -- including an oxygen bottle, a mask to breathe with and migraine medicines she takes by injection. Her attacks can come in the middle of the street or inside a store.
"For years, I have tried to hide when the pain takes over, because people are scared and shocked to see me suffer such pain. But I've stopped hiding now. It's not my fault that I get such bad headaches," says Vollan.
Now, Vollan will participate in a pilot study at the Norwegian University of Science and Technology (NTNU) where she will help in the testing of a new treatment.
Men more susceptible than women
"We also call this a suicide headache, because many sufferers become suicidal," says NTNU senior consultant and researcher Erling Tronvik.
"This is the most extreme form of a headache, and the intensity of the pain is worse than what migraine patients experience. I've had patients tell me that they bang their head against the wall because of the pain. Others say that they put their thumb in a pair of pincers while they pull with all their might, all in a desperate attempt to deflect the intense pain," says Tronvik, who is also affiliated with the Norwegian National Headache Centre at St. Olavs Hospital in Trondheim.
Unlike migraines, which mostly afflict women, cluster headaches mainly occur in men. About 5000 Norwegians suffer from cluster headaches. Some have daily seizures for a few months each year, while others have attacks several times a day, every day of the year.
Crippled by Pain
"People who get these headaches daily are crippled by the pain. It's an extremely challenging disease for both doctors and patients," Tronvik says.
Until now, it has been difficult to help these patients. Scientists do not know why some people get cluster headaches. A number of patients have found relief from injections of migraine medicine and the use of oxygen, but this treatment does not help most sufferers. The illness leaves patients with a tremendous sense of helplessness.
But now Tronvik, in collaboration with physician Daniel Bratbak at St. Olavs Hospital and Professor Ståle Nordgård at NTNU, has come up with an entirely new treatment. The gear they have developed looks a pistol with a very thin barrel, just the thickness of a knitting needle. The barrel is inserted up through the nose of the patient, and by passing through a natural hole in the nasal wall, the mouth of the barrel comes to a bundle of nerves behind the sinuses.
The surgeon pulls the trigger of the pistol, which shoots a dose of Botox to the area around the nerve bundle. The whole process takes about a half-an-hour.
In search of patients
"Botox is a neurotoxin that stops the flow of impulses along the nerves. In theory, the connection between the two nerves in the bundle is reduced or eliminated. The effect lasts from three to eight months. Then the patient has to get another injection. We designed the equipment ourselves, and Botox has never been used for this anywhere else," says Tronvik.
The researchers strongly believe in their treatment method, in part because a new study unrelated to their work has shown an effect by using an electric current to paralyse the nerve bundle.
"But that approach requires a lengthy operation," Tronvik says. Now he's in search of ten patients for a pilot study.
If the method proves to be effective, the researchers will extend the experiment to include 30 to 40 cluster headache patients and approximately 80 migraine patients. The treatment uses an MRI of the patient's head to make certain that the surgeon knows exactly where the nerve bundle is. A navigation tool, composed of three small spheres on the pistol, and a plate with three spheres mounted on the patient's head, enables the surgeon to find the nerve bundle using the MRI image.
Tested on two patients
"A computer sends light signals to all the spheres to form precise points. We don't miss, but anyone who wants to participate in the study must accept the risk that it could happen, because this has never been done before. If the Botox hits an area near the nerve bundle, it could cause temporary double vision, or weaken the ability of the patient to chew. But with the use of the MRI and our navigation tools we can hit the nerve bundle without any problem. We hope that this treatment method can help give patients a life without such great pain," says Tronvik.
Read more here

Wednesday, October 09, 2013

Botox helps rats lose weight

A study using rats showed that botox can be used as a weight loss aid.

Researchers from the Norwegian University of Science and Technology have had promising experimental results from using Botox as a weight loss tool in rats. The research group hopes to win approval for human testing in the near future.
You may know Botox from its use by the rich and famous to eliminate facial wrinkles. But now Helene Johannessen, a PhD candidate at the Norwegian University of Science and Technology (NTNU), is studying whether or not Botox could be used as an alternative to treating morbid obesity, replacing costly and dangerous operations.

Tests on rats have shown that treatments with Botox injected into the vagus nerve in the stomach can lead to weight loss. When Johannessen injected rats with Botox, the animals ate less and lost 20-30 per cent of their body weight over five weeks. The treatment effectively paralyzes the vagus nerve, which triggers the sense of hunger and controls the passing of food through the intestines.

Paralyzing the nerve paralyzes muscles in the stomach, which appears to slow the passage of food through the stomach. This effect might one day lead to treatments that cause people to feel fuller for longer.

EU project fights obesity
The hope is that the use of botox can be developed into an alternative to gastric bypass surgery. Johannessen and her research are part of the Experimental Surgery and Pharmacology research group, which is exploring alternatives to gastric surgery. The Botox treatment study is part of an EU project called Full4Health.

Botox is actually botulinum toxin, which when ingested in spoiled foods can lead to both paralysis and death. Nowadays Botox is used in the medical treatment of dystonias and spasms, as well for its more famous cosmetic use. If Johannessen and her colleagues succeed in their efforts, it might also become useful in giving people a healthier and less weighty life.
Clinical studies coming
Johannessen told the Norwegian Broadcasting Corporation (NRK) that her research team will start human clinical studies as soon as Norwegian medical ethics authorities give their approval.
"As a start, we will be inviting patients who are candidates for obesity operations but who, for one reason or another, cannot undergo one,"  Johannessen told NRK.

Obesity is a growing problem across the globe. Being overweight can lead to severe diseases and conditions including diabetes and heart problems. The World Health Organization estimates that obesity is responsible for 2-8 percent of health care costs and 10-13 percent of deaths in different parts of Europe.

Read more here

Thursday, August 22, 2013

Understanding migraine headaches

This article discusses what migraine headaches are, what we should know about them, and how to alleviate them.

Just about everybody gets a headache now and then, but migraines can feel like a world apart from what we think of as garden-variety, everyday headaches. At their worst, they bring nausea and vomiting, obscured vision and pulsating pain, leaving their victim unable to do much other than wait it out.
But the effects of migraines can span hours or even days, and with more than 37 million Americans experiencing migraine headaches, that’s a lot of time devoted to misery. Migraines can occur in anyone at any age, but are three times more common in women than men.
What causes migraines is not fully understood, but they stem from an inherited neurological disorder that causes the central nervous system to be hypersensitive, says Karen P. Lauze, MD, a neurologist with a subspecialty in headache and facial pain at Portsmouth Regional Hospital. “It’s a biological abnormality that you’re born with,” Lauze says. Many migraine sufferers have a family member who has a history of migraines.

What it feels like

Migraine symptoms vary, but often progress through phases, beginning with what are called “prodrome” warning signs that can signal an approaching migraine up to one or two days before the headache pain hits. Prodrome symptoms include irritability, excessive yawning, fluid retention, constipation and nasal congestion, Lauze says. And, “some people actually feel euphoric a day or so or hours before a migraine,” Lauze says.
In some individuals prodrome symptoms are followed by a visual aura, during which flashing lights or jagged lines appear and partially obscure their vision, or they experience other neurological symptoms, such as numbness or tingling in their hand or difficulty putting words together. Auras usually last for 10 to 60 minutes and precede headache pain, but some people have auras without ever feeling pain.
In fact, despite the common assumption that migraines bring searing head pain that prompts sufferers to seek refuge in a dark, quiet room, migraine pain can be moderate or even mild, so much so that some people don’t realize that they’re having a migraine, believing instead that they’re feeling the effects of a less-intense tension headache, Lauze says.
In other cases, though, migraine pain is “incapacitating,” says Andreja Packard, MD, PhD, a neurologist and neurophysiologist at Foundation Neurology and Southern New Hampshire Medical Center in Nashua. Typically, migraines cause throbbing pain on one side of the head. The pain can last for hours, and be accompanied by nausea and vomiting. In addition, migraines often induce sensitivity to light and sound, Packard says.
"Migraines can occur in anyone at any age, but are three times more common in women than men."
Unlike tension headaches, which can be alleviated by exercise, migraine-associated pain typically is aggravated by activity, even low-key movement, such as standing, walking and bending over, Lauze says.
After the headache pain subsides, some people experience “postdrome” symptoms, as remnants of headache effects linger. Some individuals “feel hung over for a few hours,” Lauze says, “or the following day, they feel a little achy, a little run down.”

Feeling better

Doctors commonly prescribe medication to treat migraine headaches, but patients who have frequent migraines might find themselves going under the needle— the Botox needle — as a preventive measure.
Botox injections, well known for their cosmetic application in smoothing wrinkles, can decrease the frequency and severity of migraines by about 50 percent, Packard says. “We inject it in the muscles that are involved in the spread of neck pain and head pain within the migraine,” she says. Small-gauge needles loaded with Botox are used to target seven areas of the face and neck, Packard says, amounting to about 30-plus injections. Botox prevents strenuous tightening of the muscles, relaxing them along with the surrounding area. The injections typically need to be re-administered every three months to maintain effectiveness.
Migraine sufferers can also benefit from changing personal behaviors that make migraines more likely to occur. Keeping a headache diary, for example, helps people identify and avoid headache triggers. Noting the timing of headaches leads many people to find that changes in their biological rhythm set off migraines, Lauze says. You might find that not eating regularly, eating certain foods, drinking red wine, sleeping in or not getting enough sleep, or smelling particular odors precipitates migraines. Or you might notice that you’ve been stricken with migraines while on vacation, which by definition disrupts routine, and might involve altitude changes —another known migraine trigger, Lauze says.
Doctors have found that, ideally, a mix of therapeutic approaches will be in a migraine patient’s anti-migraine toolbox. “You need to have a combination of treatments,” Packard says. In addition to receiving medicine for the headache pain and recognizing and avoiding triggers, people who experience migraines should try stress relievers like yoga, relaxation training and massages, and if needed, they should see a psychologist to help them handle stress and anxiety, she says. Behavioral therapies such as biofeedback, in which electronic monitoring is used to enhance control over bodily functions, have also proven beneficial to migraine sufferers.
But don’t try to just ignore or live with migraines. Otherwise, they might occur more frequently since being in a migraine state can become the default mode for the brain, or more commonly, frequent self-treatment with over-the-counter medicine can spur withdrawal headaches, also known as rebound headaches, on the days that you try to go without the medication, Lauze says. Left untreated, migraines can become increasingly frequent until “you’re having them almost every day, and that can just basically ruin your life and make you chronically debilitated,” Lauze says.
And trying to live with discomfort can have meaningful health consequences, particularly in people who experience pain on a regular basis. Chronic pain shortens life expectancy and increases the chance of developing many long-term disorders, Packard says, “so treatment of any chronic pain issue is wise.” 
Read more here

Monday, July 29, 2013

Medical uses and stigma associated with botox

Botox can be used to help with migraines, cerebral palsy, and overactive bladders. However, Botox users face the stigma attached with using a cosmetic product for medical purposes.

A cosmetic procedure popular among Hollywood stars can now be used to supposedly cure chronic migraines.
Botox, which is used to reverse the signs of aging is now being used to treat the neurological disorder.
More than 42,000 Kiwis suffer from chronic migraines every year and when it strikes the sufferer can be out of action for up to 72 hours.
But Botox has been proven to successfully treat the debilitating condition as well as other medical conditions.
"We can use it for cerebral palsy children, it can help them to walk again, for people who have spastic syndromes in their neck where they have chronic pain in their neck," Dr Garsing Wong from Sapphire Migraine Clinic told ONE News.
"It can even be injected into bladders, for people who over-active bladders now."
Botulinum Toxin or Botox is one of the most poisonous substances known to man, but the small dose used for treatment are less toxic than drugs you can buy over the counter.
Injections are applied to places that hold a lot of tension and through paralysing the muscle or relaxing it the treatment is able to reduce the pain at the trigger points.
But the stigma attached to Botox remains.
"The first thing, I think, that pops into your head are all those people in LA and stuff and their foreheads are literally frozen and first of you all you think; everyone's going to judge me," said Thea Lyle, Migraine Sufferer.
Ms Lyle said when she was first going to have botox to help with her migraines she was quite apprehensive about it.
But Ms Lyle is only one of hundreds of people who have had the procedure at the Sapphire Migraine Clinic.
For those who combine it with intensive physiotherapy there is a 90% success rate.
Read more here

Thursday, May 30, 2013

How to get rid of migraine headaches

This article discusses a few ways to reduce or get rid of migraine headaches.

Migraines are more than an occasional nuisance for some. Those suffering from chronic migraines know all too well the nausea, sensitivity, and unbearable pain that comes along with frequent attacks. Luckily, there are treatments available to reduce the frequency and severity of migraines.
 
Migraine treatment can be broken down into two categories; those that ease symptoms that have already started, and preventative measures that stop migraines before they start.
 
Pain-relieving medications can be taken during migraine attacks and are designed to stop symptoms that have already begun. These medications can include over-the-counters like ibuprofen and acetaminophen, but also prescription pain relievers such as indomethacin.
 
Preventative means can stop migraines from starting. Those suffering regularly from migraines might want to consider the following treatments.
 
Botox Treatments
Approved by the FDA for treating chronic migraines, injections are given around the head and neck once every 12 weeks. The Botox blocks pain signals as well as causes head and neck muscles to relax. By working on sensory pathways it reduces the sensory traffic from the head to the consciousness. 
 
Magnesium Deficiency
Studies have shown that up to 50 percent of migraine patients have lowered levels of magnesium during an attack, and an infusion of the mineral can provide rapid and sustained relief. Routine supplements can reduce the frequency and severity of such attacks. Eating magnesium-rich foods (such as nuts, whole grains, legumes, and chlorophyll-rich vegetables) can assist the body without overwhelming it. A magnesium supplement can also provide the needed boost.
 
As always, consult a certified pain physician before beginning any new treatment regimen.

Read more here

Wednesday, May 01, 2013

Chili peppers may help develop next migraine medicine

This article discusses chili peppers as a potential treatment for migraines and compares it with the success of botox injections used to treat migraines.


Chili peppers and migraines have traits in common, a fact scientists are exploiting to develop drugs capable of preventing the debilitating headache’s painful symptoms before they attack.
The link between how skin reacts when rubbed with chili oil and what happens in the brain during a migraine has attracted the world’s largest biotechnology company, Amgen Inc. (AMGN), and other companies seeking to create medicines for the more than 36 million Americans who suffer from migraines.
Symptoms include nausea, vomiting, dizziness and sensitivity to touch, yet treatment options are limited. Some pharmaceutical companies that have tried recently to develop migraine therapies, such as Bristol-Myers Squibb Co. (BMY)and Merck & Co. (MRK), have abandoned their efforts while the few drugs on the market are ineffective for many people and carry the danger of serious side effects for those at risk of heart attack or stroke.
“Migraines are an extremely common disorder, and it affects people really in the prime of their lives,” Rob Lenz, who is leading Amgen’s migraine drug development, said in an interview. Still, no drugs have been “developed specifically for the treatment of migraines,” he said. “They were developed as anti-epileptics, or blood pressure lowering agents.”
That may soon change. Amgen, based in Thousand Oaks,California, and other biotechnology companies such as Alder Biopharmaceuticals Inc., Arteaus Therapeutics LLC, and Labrys Biologics Inc. are targeting a chemical released during a migraine that carries a “pain” signal from nerve to nerve. By blocking a receptor from receiving the message, these companies aim to create drugs that cut off developing migraines before symptoms start.

Targeted Injections

Similar pain-signal transmission occurs when chili oil touches the skin. In that situation, the capsaicin in the pepper causes the body to release calcitonin gene-related peptides, or CGRP, leading to an increase in blood flow to the affected area. To show the Amgen drug works, researchers injected it under the skin of patients who had chili oil on their skin. The therapy blocked the CGRP that causes increased blood flow.
“It sounds simple, but it’s important -- it tells us that our drug is getting into the body in relative concentrations that are generally well tolerated and that block CGRP,” Lenz said.
The new class of drugs under development are biologics, often delivered by injection, and are more complex, targeted and longer lasting in the body than the earlier failed attempts, Lenz said.

Sales Potential

Amgen’s AMG 334 and Alder’s ALD 403 are being tested in the second of three clinical trials typically required for U.S. regulatory approval.
“We’ll have data on this before the year is out,” Randall Schatzman, chief executive officer of closely held Alder, based in Bothell, Washington, said in an interview.
If those trials yield results, the sales potential for these drugs will be significant. Michael Yee, an analyst with RBC Capital Markets in San Francisco, said Amgen’s new migraine treatment may reach $1 billion in sales should it gain approval.
Allergan Inc. (AGN)’s Botox, used primarily for cosmetic treatments, is also approved as a preventative therapy for migraines, though only for severe sufferers who have attacks lasting four hours or more at least 15 days a month. That means only about 10 percent of migraine patients qualify for that option. Sales for Botox as a migraine treatment alone could reach $1 billion during the next decade, Anne-Elise Tobin, an analyst with Burlington, Massachusetts-based Decision Resources, said in an interview. The new class of drugs would be for a bigger patient population with less frequent migraines.

Botox Success

“Botox demonstrates the market potential for a new emerging prophylaxis therapy,” said Tobin, who estimates the global market for all migraine treatments should increase 87 percent to $5.8 billion in 2021 from $3.1 billion in 2011.
Amgen gained 1.8 percent to $113.42 in New York. The stock gained 34 percent in 2012, its best annual increase since 1999, as investors rewarded the company for its buyback program, dividend and sales increase.
Currently, the most popular migraine treatments are oral drugs called triptans, first introduced in the 1990s, such as GlaxoSmithKline Plc’s Imitrex, which constrict blood vessels in the brain to relieve swelling and pain.

Pain Blockers

Those medicines attempt to halt migraines once they begin. The new therapies aim to eliminate the need to wait for attacks to occur, said John Latham, chief scientific officer at Alder.
“Once the migraine symptoms flair, it’s very hard to resolve them, and most of the people at that stage of the game let it run its course,” Latham said in a phone interview. “You can go into a dark room, turn the lights off, put ear plugs on, use an ice pack, but there’s not much you can do pharmaceutically to kick the migraine back in its place.”
That’s why the new pain blocker approach holds so much promise. By blocking a receptor in the brain from receiving the message, migraines could be avoided completely, said Peter Goadsby, director of the University of California, San Francisco’s Headache Center. Goadsby helped discover CGRP’s connection to migraines and has consulted with drug companies working on developing his findings into medicines.
“What these antibody approaches hope to do is to either block the receptor or mop up the CGRP itself,” he said.
This isn’t the first time drugmakers have targeted CGRP to stop migraines. Bristol-Myers and Merck were working a few years ago on so-called small molecule therapies, taken orally, to prevent headaches. While Merck’s drug, telcagepant, worked better than a placebo in a study, the company shelved development on concerns about liver damage. Bristol-Myers also said it wouldn’t continue development of its drug.
“The whole migraine world was thrown into a tizzy because this was supposed to be the next big thing,” Cathy Glaser, president and co-founder of the Migraine Research Foundation, said in an interview. “We’re all looking for the next magic pill.”
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Sunday, April 21, 2013

Child finds migraine relief from Botox

This article discusses a succes story about a child whose chronic migraines were treated by botox injections.

There is nothing worse than a bad headache, but now imagine living with debilitating migraines.

Turns out that's the reality for 5 to 10 percent of all children in the United States. But now there is hope and it's coming in the form of a very popular beauty treatment.

Valerie Portolano, 17, is no stranger to migraines.

"I'm not really a headache, I'm a chronic migraine," she said. "I have a headache every single day of my life."

Portolano has tried just about everything to relieve her pain but today she's trying something new. The treatment is Botox!

Portolano hopes, "I will have some less pain and also get to live a little."

Sixteen-year-old Delanie Mattson is proof of that.

"Yeah it's weird but it works," she said.

Mattson's had migraines since she was 13.

"It was sad," said her mother, Carrie Mattson. "She lost out on a lot of life because of her migraines."

Mattson was home-schooled and had to give up her passion for playing softball all because of her migraines. She was even taking Vicodin nightly just to sleep. That is until she started getting Botox injections last summer.

"It's a relief knowing I'm not going to get a migraine," she said.

Botox has been widely used to treat migraines in adults since 2010.

"This is definitely an off-label use," said Dr. Marcy Yonker, a pediatric neurologist headache specialist with Phoenix Children's Hospital. "There's no indication for this in treating children."

Yonker is one of only about 20 pediatric headache specialists in the nation.

"In children in whom I thought nothing would ever help them, headache free, so I was really shocked," she said.

The kids first have numbing cream applied that helps take the edge off the 31 shots of Botox they get in their forehead, scalp and shoulders.

"As the medicine goes in it sort of burns, so it does hurt but it's worth it," said 17-year-old Tatum Amato.

"It seems to change the activity of the pain fibers that tell people they have a migraine," Yonker explained.

But she points out this isn't necessarily a cure.

"We don't know whether it is stopping the migraine or if they are not feeling the migraine," she said.

Regardless, the Botox seems to be breathing new life into these kids' lives. Like Amato, who was once a competitive cheerleader but her migraines robbed her of that.

Now, just after one round of Botox, she said, "I don't get migraines as often and if I do they are not as severe."

The long-term effects of this headache treatment are still unknown, especially in children.

"Is there going to be muscle wasting for them? Are they going to develop some numbness? That's something we really need to look at," Yonker said.

To qualify for this treatment in the headache clinic at Phoenix Children's Hospital, kids must have chronic migraines, meaning they have headaches 15 days a month that last more than four hours a day.

Read more here

Wednesday, April 17, 2013

Botox helps 3-year old with cerebral palsy walk

This article discusses the beneficial effect botox injections had for a 3 year old with cerebral palsy. The botox injections helped him walk for the first time.


Brave tot Aiden Farrell has taken his first steps after having Botox injections in his legs.
3-year-old Aiden was born with crippling cerebral palsy and his muscles tightened up so much so he was unable to straighten his legs without pain.
The toddler's parents Sara and Gevun scoured the Internet for treatment and discovered that Botox could be the answer.
The injections, most commonly used cosmetically to prevent wrinkles, work for Aiden by unblocking nerve impulses which restrict his movement.
Mom of four Sara, 31, said: "Seeing Aiden take his first steps is something I never dreamed would be possible.
"I noticed as soon as we got home after having the treatment the difference was amazing.



"Usually he would sit on the sofa with his legs bent up but his legs were normal, like ours would be when we sit on the sofa.

"It may sound unusual but if it helps my little boy walk I do not care.

"It is about trying to build up strength in his length and walk more. He is using muscles he has never used before.

"The difference in mobility is unbelievable."



Aiden has suffered health problems all his young life after being born prematurely at 29 weeks.

He weighed just 3 lbs. and had to be kept alive on a ventilator.



Full time mom Sara and builder Gevun of Hampshire, UK, first feared there could be something seriously wrong with him when he struggled to sit up aged eight months.

Sara added: "When I was told Aiden had cerebral palsy we grieved every day, especially because we have other children and could see them running around the house.

"It was difficult because we wanted Aiden to do the same things they could do.

"Over time his legs tightened up so much he was unable to straighten them. He would cry with any physiotherapy exercises he was given to strengthen his legs.

"I felt useless because all I could do was massage them to make his pain go away."

After Sara and Gevun read about the Botox treatment online Aiden was placed on an 18-month waiting list and in 

December last year was given 12 injections, two in each of his calves, hamstrings and groin.


The family were told there was only a 50 per cent chance of it being successful.

Sara added: "I was really nervous taking him to the hospital that morning.

"When it's your own child you really want it to work but of course you have your doubts about what will happen if it doesn't.

"He was put to sleep and we were originally told he would be down for four minutes but it was an hour by the time we got called to see him.

"But when we did he asked for a sausage roll - which made everyone laugh."

The unconventional treatment has had a life-changing effect on the family.

For the first time Aiden is able to stand, walk with his legs straighter on his walking frame, stand with his legs apart and even take a few steps on his own.

Sara was finally able to fulfil her dream of being able to push toy cars through his legs, like she had done with her other children.

Botox uses tiny amounts of botulinum toxin, derived from the bacteria that cause botulism food poisoning.

The deadly nerve agent kills by paralysing the muscles used for breathing.

In tiny doses it relaxes the contraction of muscles in some people with cerebral palsy by blocking nerve impulses.

This allows better control of movement and reduces the risk of muscle and tendon shortening. The effects last between four and six months.

The family are now hoping Aiden will be eligible for selective dorsal rhizotomy surgery - a five-hour operation which will cut the nerves in his lower back and provide a permanent cure.

Read more here