Showing posts with label how do you treat migraine. Show all posts
Showing posts with label how do you treat migraine. Show all posts

Monday, August 18, 2014

How to manage your migraine headaches

This article discusses how to manage and cope with migraine headaches.

Migraines can be debilitating, and can affect people in different ways. There may be blurred vision, a pulsating headache, nausea, vomiting, etc. They can negatively affect your work, social life and general well-being. Therefore, learning ways of coping with migraines is very important.
Migraines occur when certain arteries in your head constrict and dilate. This may stimulate a pain response in some nerves.
Although the exact mechanisms that cause migraines are not clearly understood, there are a number of factors that have been associated with increased incidence and severity of these headaches. These may include hormones, mental state, diet and environment.
The hormonal fluctuations in a woman's menstrual cycle often trigger migraines. If women suffer from migraines during other times, they are often not as severe. Furthermore, hormonally induced mood changes are also associated with migraines.
Your mental state is an important consideration in these headaches. Stress (including Post Traumatic Stress Disorder) and depression have both been associated with increased incidence, as has chemical exposures and even obesity.
Diet is obviously an important consideration. The foods we eat can not only affect our weight, but also have the potential to trigger migraines in other ways. Food sensitivities should definitely be considered in treating migraines, as their elimination may decrease the amount of migraines experienced.
Because so many imbalances are associated with migraine headaches, working toward correcting the imbalances that contribute to migraine triggers are an important aspect of treatment.
Therapies such as herbal and homeopathic remedies in combination with lifestyle choices and diet may be used to gently detoxify your body. This may be used to help eliminate harmful chemicals and toxins, thus supporting the normal function of your body. By doing this, the factors affecting hormonal imbalances and chemical triggers may be reduced.
Another treatment that may be considered is acupuncture. Acupuncture may be used to balance your body's energetic system and is an amazing tool for pain relief.
By working toward bringing balance to your body and mind, a number of factors such as your hormones and mental and emotional well-being may be improved. By improving these factors, it may be possible to reduce the incidence and severity of the migraines you experience.
Read more here

Tuesday, August 12, 2014

Common treatments for migraines

This article provides information on migraine headaches and discusses treatments for migraine headaches.

Suffering from migraines can have a seriously negative impact on both your work and social life, but what exactly causes those splitting headaches?

Men, women and children can suffer from migraines. Some people may have a migraine as often as a few times a week, whereas others might only experience them occasionally.
According to the NHS, there are several types of migraine. These include:
  • Migraine with aura – where there are warning signs before the migraine begins, such as seeing flashing lights.
  • Migraine without aura – where the migraine occurs without warning signs.
  • Migraine aura without headache, also known as silent migraine – where an aura or other migraine symptoms are experienced, but a headache does not develop.
Although the exact cause of migraine is unknown, triggers are thought to include hormonal, emotional, physical, dietary, environmental and medical changes to your usual routine.
If you suffer from regular migraines it is important to visit your GP, as some experts have found migraines to indicate other underlying health issues such as abnormal blood vessel structure in the brain.
Migraine remains undiagnosed and under-treated in at least 50% of patients, and less than 50% of migraine patients consult a physician – but your GP could really help you to reduce your suffering.
GPs can help you to identify the triggers of your migraine and also prescribe medication to help you manage your condition like painkillers, triptans (medications that can help reverse the changes in the brain that may cause migraines), or anti-emetics (medications often used to reduce nausea and vomiting).
Read more here

Monday, November 11, 2013

Botox to treat extreme cluster headaches

Botox could be used to help treat extremely painful cluster headaches and migraine headaches.

"I hit myself in the head to distract myself from the pain when I have a cluster headache. The pain is indescribable hell, and in desperate moments, I have hit my head against a brick wall and hit myself in the head with a cell phone," says Hilde Vollan (34), a PhD candidate in bioinformatics at the University of Oslo.
Four years and four months ago, her life turned upside down when she started getting cluster headaches. Her life has been transformed -- once, she was an active student with many friends, but she now lives a life in the dark at home with her parents. She has two to five cluster headaches every day, and also suffers from migraine and tension headaches. If she dares to go out for a walk, she always brings someone who can support her, and a bag of pills -- including an oxygen bottle, a mask to breathe with and migraine medicines she takes by injection. Her attacks can come in the middle of the street or inside a store.
"For years, I have tried to hide when the pain takes over, because people are scared and shocked to see me suffer such pain. But I've stopped hiding now. It's not my fault that I get such bad headaches," says Vollan.
Now, Vollan will participate in a pilot study at the Norwegian University of Science and Technology (NTNU) where she will help in the testing of a new treatment.
Men more susceptible than women
"We also call this a suicide headache, because many sufferers become suicidal," says NTNU senior consultant and researcher Erling Tronvik.
"This is the most extreme form of a headache, and the intensity of the pain is worse than what migraine patients experience. I've had patients tell me that they bang their head against the wall because of the pain. Others say that they put their thumb in a pair of pincers while they pull with all their might, all in a desperate attempt to deflect the intense pain," says Tronvik, who is also affiliated with the Norwegian National Headache Centre at St. Olavs Hospital in Trondheim.
Unlike migraines, which mostly afflict women, cluster headaches mainly occur in men. About 5000 Norwegians suffer from cluster headaches. Some have daily seizures for a few months each year, while others have attacks several times a day, every day of the year.
Crippled by Pain
"People who get these headaches daily are crippled by the pain. It's an extremely challenging disease for both doctors and patients," Tronvik says.
Until now, it has been difficult to help these patients. Scientists do not know why some people get cluster headaches. A number of patients have found relief from injections of migraine medicine and the use of oxygen, but this treatment does not help most sufferers. The illness leaves patients with a tremendous sense of helplessness.
But now Tronvik, in collaboration with physician Daniel Bratbak at St. Olavs Hospital and Professor Ståle Nordgård at NTNU, has come up with an entirely new treatment. The gear they have developed looks a pistol with a very thin barrel, just the thickness of a knitting needle. The barrel is inserted up through the nose of the patient, and by passing through a natural hole in the nasal wall, the mouth of the barrel comes to a bundle of nerves behind the sinuses.
The surgeon pulls the trigger of the pistol, which shoots a dose of Botox to the area around the nerve bundle. The whole process takes about a half-an-hour.
In search of patients
"Botox is a neurotoxin that stops the flow of impulses along the nerves. In theory, the connection between the two nerves in the bundle is reduced or eliminated. The effect lasts from three to eight months. Then the patient has to get another injection. We designed the equipment ourselves, and Botox has never been used for this anywhere else," says Tronvik.
The researchers strongly believe in their treatment method, in part because a new study unrelated to their work has shown an effect by using an electric current to paralyse the nerve bundle.
"But that approach requires a lengthy operation," Tronvik says. Now he's in search of ten patients for a pilot study.
If the method proves to be effective, the researchers will extend the experiment to include 30 to 40 cluster headache patients and approximately 80 migraine patients. The treatment uses an MRI of the patient's head to make certain that the surgeon knows exactly where the nerve bundle is. A navigation tool, composed of three small spheres on the pistol, and a plate with three spheres mounted on the patient's head, enables the surgeon to find the nerve bundle using the MRI image.
Tested on two patients
"A computer sends light signals to all the spheres to form precise points. We don't miss, but anyone who wants to participate in the study must accept the risk that it could happen, because this has never been done before. If the Botox hits an area near the nerve bundle, it could cause temporary double vision, or weaken the ability of the patient to chew. But with the use of the MRI and our navigation tools we can hit the nerve bundle without any problem. We hope that this treatment method can help give patients a life without such great pain," says Tronvik.
Read more here

Thursday, August 22, 2013

Understanding migraine headaches

This article discusses what migraine headaches are, what we should know about them, and how to alleviate them.

Just about everybody gets a headache now and then, but migraines can feel like a world apart from what we think of as garden-variety, everyday headaches. At their worst, they bring nausea and vomiting, obscured vision and pulsating pain, leaving their victim unable to do much other than wait it out.
But the effects of migraines can span hours or even days, and with more than 37 million Americans experiencing migraine headaches, that’s a lot of time devoted to misery. Migraines can occur in anyone at any age, but are three times more common in women than men.
What causes migraines is not fully understood, but they stem from an inherited neurological disorder that causes the central nervous system to be hypersensitive, says Karen P. Lauze, MD, a neurologist with a subspecialty in headache and facial pain at Portsmouth Regional Hospital. “It’s a biological abnormality that you’re born with,” Lauze says. Many migraine sufferers have a family member who has a history of migraines.

What it feels like

Migraine symptoms vary, but often progress through phases, beginning with what are called “prodrome” warning signs that can signal an approaching migraine up to one or two days before the headache pain hits. Prodrome symptoms include irritability, excessive yawning, fluid retention, constipation and nasal congestion, Lauze says. And, “some people actually feel euphoric a day or so or hours before a migraine,” Lauze says.
In some individuals prodrome symptoms are followed by a visual aura, during which flashing lights or jagged lines appear and partially obscure their vision, or they experience other neurological symptoms, such as numbness or tingling in their hand or difficulty putting words together. Auras usually last for 10 to 60 minutes and precede headache pain, but some people have auras without ever feeling pain.
In fact, despite the common assumption that migraines bring searing head pain that prompts sufferers to seek refuge in a dark, quiet room, migraine pain can be moderate or even mild, so much so that some people don’t realize that they’re having a migraine, believing instead that they’re feeling the effects of a less-intense tension headache, Lauze says.
In other cases, though, migraine pain is “incapacitating,” says Andreja Packard, MD, PhD, a neurologist and neurophysiologist at Foundation Neurology and Southern New Hampshire Medical Center in Nashua. Typically, migraines cause throbbing pain on one side of the head. The pain can last for hours, and be accompanied by nausea and vomiting. In addition, migraines often induce sensitivity to light and sound, Packard says.
"Migraines can occur in anyone at any age, but are three times more common in women than men."
Unlike tension headaches, which can be alleviated by exercise, migraine-associated pain typically is aggravated by activity, even low-key movement, such as standing, walking and bending over, Lauze says.
After the headache pain subsides, some people experience “postdrome” symptoms, as remnants of headache effects linger. Some individuals “feel hung over for a few hours,” Lauze says, “or the following day, they feel a little achy, a little run down.”

Feeling better

Doctors commonly prescribe medication to treat migraine headaches, but patients who have frequent migraines might find themselves going under the needle— the Botox needle — as a preventive measure.
Botox injections, well known for their cosmetic application in smoothing wrinkles, can decrease the frequency and severity of migraines by about 50 percent, Packard says. “We inject it in the muscles that are involved in the spread of neck pain and head pain within the migraine,” she says. Small-gauge needles loaded with Botox are used to target seven areas of the face and neck, Packard says, amounting to about 30-plus injections. Botox prevents strenuous tightening of the muscles, relaxing them along with the surrounding area. The injections typically need to be re-administered every three months to maintain effectiveness.
Migraine sufferers can also benefit from changing personal behaviors that make migraines more likely to occur. Keeping a headache diary, for example, helps people identify and avoid headache triggers. Noting the timing of headaches leads many people to find that changes in their biological rhythm set off migraines, Lauze says. You might find that not eating regularly, eating certain foods, drinking red wine, sleeping in or not getting enough sleep, or smelling particular odors precipitates migraines. Or you might notice that you’ve been stricken with migraines while on vacation, which by definition disrupts routine, and might involve altitude changes —another known migraine trigger, Lauze says.
Doctors have found that, ideally, a mix of therapeutic approaches will be in a migraine patient’s anti-migraine toolbox. “You need to have a combination of treatments,” Packard says. In addition to receiving medicine for the headache pain and recognizing and avoiding triggers, people who experience migraines should try stress relievers like yoga, relaxation training and massages, and if needed, they should see a psychologist to help them handle stress and anxiety, she says. Behavioral therapies such as biofeedback, in which electronic monitoring is used to enhance control over bodily functions, have also proven beneficial to migraine sufferers.
But don’t try to just ignore or live with migraines. Otherwise, they might occur more frequently since being in a migraine state can become the default mode for the brain, or more commonly, frequent self-treatment with over-the-counter medicine can spur withdrawal headaches, also known as rebound headaches, on the days that you try to go without the medication, Lauze says. Left untreated, migraines can become increasingly frequent until “you’re having them almost every day, and that can just basically ruin your life and make you chronically debilitated,” Lauze says.
And trying to live with discomfort can have meaningful health consequences, particularly in people who experience pain on a regular basis. Chronic pain shortens life expectancy and increases the chance of developing many long-term disorders, Packard says, “so treatment of any chronic pain issue is wise.” 
Read more here

Wednesday, May 01, 2013

Everything you should know about migraines

This article discusses many aspects of migraines such as what causes them and how to treat them.


Migraines can loosely be described as recurrent moderate to severe headaches that is typically unilateral, that is, pain occurring on side of the head. Associated symptoms may include nausea, vomiting, photophobia (increased sensitivity to light), phonophobia (increased sensitivity to sound) and the pain is generally aggravated by physical activity. Up to one-third of people with migraine headaches perceive an aura: a transient visual, sensory, language, or motor disturbance which signals that the headache will soon occur. Occasionally an aura can occur with little or no headache following it.

What causes migraines?

The underlying causes of migraines are unknown. However, they are believed to be related to a mix of environmental and genetic factors. They run in families in about two-thirds of cases and rarely occur due to a single gene defect.

There have been stipulations that migraines are caused by expanded blood vessels in the brain. However, the pain of migraine headaches might not be caused by expanded blood vessels in the brain, as previously thought. Instead, the real culprit may be overactive pain-signal firing in brain cells, new research suggests. These findings were published on April 9th in the journal Lancet Neurology, come from studying the brain scans of patients as they were suffering from a migraine.

Moreover, there are several treatments being developed that could address this signaling and, in turn, help treat migraine pain. However, further studies are needed to confirm that the overactive signaling is a cause of migraine pain.

How can migraines be cured?

Preventive migraine medications are considered effective if they reduce the frequency or severity of the migraine attacks by at least 50%. Common drugs used in Ghana to help with the pain are Cafergot (combination of drugs; ergotamine tatrate and caffeine), topiramate, propranolol, and metoprolol. Other household methods that can help are as follows:

a. Getting a good night’s sleep

b. Keep the room dark

c. Take Caffeine; it's a paradox of headaches: ingest too much caffeine and you may get a headache, but take a little bit and it can help make the pain disappear

d. Ice packs. Lie down and put an ice pack or cold compress on your head. Close your eyes while doing that.

Read more here

Chili peppers may help develop next migraine medicine

This article discusses chili peppers as a potential treatment for migraines and compares it with the success of botox injections used to treat migraines.


Chili peppers and migraines have traits in common, a fact scientists are exploiting to develop drugs capable of preventing the debilitating headache’s painful symptoms before they attack.
The link between how skin reacts when rubbed with chili oil and what happens in the brain during a migraine has attracted the world’s largest biotechnology company, Amgen Inc. (AMGN), and other companies seeking to create medicines for the more than 36 million Americans who suffer from migraines.
Symptoms include nausea, vomiting, dizziness and sensitivity to touch, yet treatment options are limited. Some pharmaceutical companies that have tried recently to develop migraine therapies, such as Bristol-Myers Squibb Co. (BMY)and Merck & Co. (MRK), have abandoned their efforts while the few drugs on the market are ineffective for many people and carry the danger of serious side effects for those at risk of heart attack or stroke.
“Migraines are an extremely common disorder, and it affects people really in the prime of their lives,” Rob Lenz, who is leading Amgen’s migraine drug development, said in an interview. Still, no drugs have been “developed specifically for the treatment of migraines,” he said. “They were developed as anti-epileptics, or blood pressure lowering agents.”
That may soon change. Amgen, based in Thousand Oaks,California, and other biotechnology companies such as Alder Biopharmaceuticals Inc., Arteaus Therapeutics LLC, and Labrys Biologics Inc. are targeting a chemical released during a migraine that carries a “pain” signal from nerve to nerve. By blocking a receptor from receiving the message, these companies aim to create drugs that cut off developing migraines before symptoms start.

Targeted Injections

Similar pain-signal transmission occurs when chili oil touches the skin. In that situation, the capsaicin in the pepper causes the body to release calcitonin gene-related peptides, or CGRP, leading to an increase in blood flow to the affected area. To show the Amgen drug works, researchers injected it under the skin of patients who had chili oil on their skin. The therapy blocked the CGRP that causes increased blood flow.
“It sounds simple, but it’s important -- it tells us that our drug is getting into the body in relative concentrations that are generally well tolerated and that block CGRP,” Lenz said.
The new class of drugs under development are biologics, often delivered by injection, and are more complex, targeted and longer lasting in the body than the earlier failed attempts, Lenz said.

Sales Potential

Amgen’s AMG 334 and Alder’s ALD 403 are being tested in the second of three clinical trials typically required for U.S. regulatory approval.
“We’ll have data on this before the year is out,” Randall Schatzman, chief executive officer of closely held Alder, based in Bothell, Washington, said in an interview.
If those trials yield results, the sales potential for these drugs will be significant. Michael Yee, an analyst with RBC Capital Markets in San Francisco, said Amgen’s new migraine treatment may reach $1 billion in sales should it gain approval.
Allergan Inc. (AGN)’s Botox, used primarily for cosmetic treatments, is also approved as a preventative therapy for migraines, though only for severe sufferers who have attacks lasting four hours or more at least 15 days a month. That means only about 10 percent of migraine patients qualify for that option. Sales for Botox as a migraine treatment alone could reach $1 billion during the next decade, Anne-Elise Tobin, an analyst with Burlington, Massachusetts-based Decision Resources, said in an interview. The new class of drugs would be for a bigger patient population with less frequent migraines.

Botox Success

“Botox demonstrates the market potential for a new emerging prophylaxis therapy,” said Tobin, who estimates the global market for all migraine treatments should increase 87 percent to $5.8 billion in 2021 from $3.1 billion in 2011.
Amgen gained 1.8 percent to $113.42 in New York. The stock gained 34 percent in 2012, its best annual increase since 1999, as investors rewarded the company for its buyback program, dividend and sales increase.
Currently, the most popular migraine treatments are oral drugs called triptans, first introduced in the 1990s, such as GlaxoSmithKline Plc’s Imitrex, which constrict blood vessels in the brain to relieve swelling and pain.

Pain Blockers

Those medicines attempt to halt migraines once they begin. The new therapies aim to eliminate the need to wait for attacks to occur, said John Latham, chief scientific officer at Alder.
“Once the migraine symptoms flair, it’s very hard to resolve them, and most of the people at that stage of the game let it run its course,” Latham said in a phone interview. “You can go into a dark room, turn the lights off, put ear plugs on, use an ice pack, but there’s not much you can do pharmaceutically to kick the migraine back in its place.”
That’s why the new pain blocker approach holds so much promise. By blocking a receptor in the brain from receiving the message, migraines could be avoided completely, said Peter Goadsby, director of the University of California, San Francisco’s Headache Center. Goadsby helped discover CGRP’s connection to migraines and has consulted with drug companies working on developing his findings into medicines.
“What these antibody approaches hope to do is to either block the receptor or mop up the CGRP itself,” he said.
This isn’t the first time drugmakers have targeted CGRP to stop migraines. Bristol-Myers and Merck were working a few years ago on so-called small molecule therapies, taken orally, to prevent headaches. While Merck’s drug, telcagepant, worked better than a placebo in a study, the company shelved development on concerns about liver damage. Bristol-Myers also said it wouldn’t continue development of its drug.
“The whole migraine world was thrown into a tizzy because this was supposed to be the next big thing,” Cathy Glaser, president and co-founder of the Migraine Research Foundation, said in an interview. “We’re all looking for the next magic pill.”
Read more here

Saturday, March 09, 2013

Tonight honey, I have a headache: Migraine Headaches Relieved by Sex

This article discusses a study that found that sex works as well as medication at relieving migraine headaches. 

I'm certainly not ready to make this recommendation in the office....awkward....

As an aside, I am not sure how they would do more research on this topic.JR


Maybe Marvin Gaye was right.

Researchers say sexual healing — as the crooner suggested, in his so-titled hit — is not all in the head. In fact, having sex can actually cure what ails the head.

More than half of migraine sufferers said their pain subsided when they had sex, researchers found. And one in five who took part in the study said their pain disappeared completely, The Daily Mail reported.

“Our results show that sexual activity during a migraine attack might relieve or even stop an attack in some cases, and that sexual activity in the presence of headache is not an unusual behavior,” researchers found, The Daily Mail reported. “Sex can abort migraine and cluster headache attacks.”

The studies were conducted at the University of Munster in Germany. They involved 400 patients suffering from two different types of headaches, cluster and migraines. One neurologist emphasized that the findings were preliminary. But they’re significant enough to moot at least one age-old excuse.

“We can now say, however, that the excuse of ‘not tonight, I have a headache,’ may not be taken seriously by all sexual partners,” said Nick Silver, a consultant neurologist at the NHS Walton Centre for Neuroscience and Neurosurgery in Liverpool, in The Daily Mail report.


Read more here


Saturday, October 20, 2012

Botox Injections Can Help Reduce Chronic Neck and Cervical Muscle Pain

A new study shows that Botox injections can help make certain pains in the neck and shoulders less severe. The study also showed that those who received botox injections had less frequent headaches.

A study presented at the Anesthesiology 2012™ annual meeting revealed Botulinum toxin type A (BOTOX) injections significantly improve pain and quality of life in people with chronic bilateral posterior neck and shoulder myofascial pain syndrome.

Traditional therapies for the treatment of myofascial pain syndrome include medications such as anti-inflammatory drugs (such as ibuprofen or naproxen), steroids and muscle relaxants, physical therapy and behavioral modification.
"At best, long-term benefit with traditional therapies is transient and unpredictable," said Andrea L. Nicol, M.D., M.S., Director of Research -- UCLA Pain Management Center, Assistant Clinical Professor, Department of Anesthesiology -- Division of Pain Management, David Geffen School of Medicine at UCLA. "Even with these treatments, some people with myofascial pain syndrome get incomplete benefit or no benefit at all."
BOTOX is used commercially to treat multiple painful medical conditions, including migraine headaches, spasticity and cervical dystonia. It is also used cosmetically as a means of reducing the appearance of frown lines and wrinkles.
"BOTOX is in a class of medications called neurotoxins and when injected into muscles, blocks the nerve signals that cause the tightening of muscle, leading to muscle relaxation. Thus, BOTOX may offer advantages over traditional therapies for myofascial pain syndrome due to its prolonged and sustained effects," Dr. Nicol confirmed.
About the Study
The study was conducted at the University of California, Los Angeles by Chronic Pain Management Specialists F. Michael Ferrante, M.D. and Andrea Nicol, M.D. All subjects who enrolled in the study were given injections of BOTOX into the painful muscles of the neck and shoulder area during the first phase of the study. Subjects with significant improvement to BOTOX treatment moved on to the second phase of the study and were randomized into two groups. Subjects in the treatment group had BOTOX injections into the painful muscles of the neck and shoulder area. Subjects in the control group received a placebo injection (salt water) into the painful muscles of the neck and shoulder.
Those enrolled in the study were monitored intermittently to assess their response to the injections. Pain scales and questionnaires were administered to document response and perform data analysis.
Analysis of the results revealed subjects who received BOTOX injections had:
  • A significantly greater reduction of their pain scores compared to those subjects who had received placebo injections.
  • A significant reduction in the number of headaches they experienced on a weekly basis.
    • The severity of the subjects' headaches (numerical pain score rating) was reduced.
  • A significant reduction in the interference of their pain with regards to general activity, sleep and enjoyment, indicating an overall improved quality of life.
Given the findings of this study, BOTOX may be an option for those who have been suffering with myofascial pain syndrome and have yet to find relief with traditional therapies.
Read more here

Sunday, October 09, 2011

Botox reduces the impact of chronic migraine

This article summarizes data supporting the use of "botox" for migraine treatment. JR

Neurology. 2011 Sep 28. [Epub ahead of print]

OnabotulinumtoxinA improves quality of life and reduces impact of chronic migraine.

Source

From the Albert Einstein College of Medicine (R.B.L., B.G.), Bronx; Montefiore Headache Center (R.B.L., B.G.), Bronx, NY; Allergan, Inc. (S.F.V., R.E.D., C.C.T.), Irvine, CA; Associated Neurologists of Southern Connecticut (P.J.M.), Fairfield, CT; Baylor University Medical Center (F.F.), Dallas, TX; Swedish Neuroscience Institute (S.K.A.), Seattle, WA; Mayo Clinic Arizona (D.W.D.), Phoenix; Thomas Jefferson University (S.D.S.), Philadelphia, PA; University of Essen (H.C.D.), Essen, Germany; and Imprint Publication Science (M.E.N.), New York, NY.

Abstract

OBJECTIVE:

To assess the effects of treatment with onabotulinumtoxinA (Botox, Allergan, Inc., Irvine, CA) on health-related quality of life (HRQoL) and headache impact in adults with chronic migraine (CM).

METHODS:

The Phase III Research Evaluating Migraine Prophylaxis Therapy (PREEMPT) clinical program (PREEMPT 1 and 2) included a 24-week, double-blind phase (2 12-week cycles) followed by a 32-week, open-label phase (3 cycles). Thirty-one injections of 5U each (155 U of onabotulinumtoxinA or placebo) were administered to fixed sites. An additional 40 U could be administered "following the pain." Prespecified analysis of headache impact (Headache Impact Test [HIT]-6) and HRQoL (Migraine-Specific Quality of Life Questionnaire v2.1 [MSQ]) assessments were performed. Because the studies were similar in design and did not notably differ in outcome, pooled results are presented here.

RESULTS:

A total of 1,384 subjects were included in the pooled analyses (onabotulinumtoxinA, n = 688; placebo, n = 696). Baseline mean total HIT-6 and MSQ v2.1 scores were comparable between groups; 93.1% were severely impacted based on HIT-6 scores ≥60. At 24 weeks, in comparison with placebo, onabotulinumtoxinA treatment significantly reduced HIT-6 scores and the proportion of patients with HIT-6 scores in the severe range at all timepoints including week 24 (p < 0.001). OnabotulinumtoxinA treatment significantly improved all domains of the MSQ v2.1 at 24 weeks (p < 0.001).

CONCLUSIONS:

Treatment of CM with onabotulinumtoxinA is associated with significant and clinically meaningful reductions in headache impact and improvements in HRQoL.Classification of evidence:This study provides Class 1A evidence that onabotulinumtoxinA treatment reduces headache impact and improves HRQoL.
PMID:
 
21956721
 
[PubMed - as supplied by publisher]