Babies with low birth weight: what correlates with development at term?

J Pediatr. 2014 Jan 30. pii: S0022-3476(13)01576-X. doi: 10.1016/j.jpeds.2013.12.030. [Epub ahead of print]

Electroencephalographic Characteristics in Preterm Infants Born with Intrauterine Growth Restriction.

Yerushalmy-Feler A1, Marom R2, Peylan T3, Korn A4, Haham A2, Mandel D2, Yarkoni I2, Bassan H3.

Author information

Abstract

OBJECTIVE:

To determine the impact of fetal growth on postnatal amplitude-integrated electroencephalography (aEEG) and power spectrum electroencephalography (EEG) data in preterm infants born with intrauterine growth restriction (IUGR).

STUDY DESIGN:

We defined IUGR as birth weight <10th 48="" administered="" aeeg="" age="" analysis="" analyzed="" and="" appropriate="" as="" assessment="" bands="" before="" birth="" by="" calculated.="" control="" discharge.="" during="" eeg="" first="" for="" frequency="" gestational="" hours="" infant="" lacey="" life="" lower="" margins="" measured="" of="" p="" percentile="" performed="" power="" preterm="" readings="" relative="" single-channel="" spectral="" the="" trace="" upper="" was="" we="" weight="" were="" width.="">

RESULTS:

We enrolled 14 infants with IUGR (mean GA, 34.3 ± 1.8 weeks; mean birth weight 1486 ± 304 g) and 16 appropriate for GA controls (mean GA, 33.7 ± 2 weeks; mean birth weight, 1978 ± 488 g). There were no significant between-group differences in perinatal complications. The mean aEEG trace width was 20.8 ± 1.4 μv in the infants with IUGR versus 17.3 ± 1.6 μv in controls (P < .001). The infants with IUGR also had significantly greater delta frequency activity and decreased theta, alpha, and beta frequency activities compared with controls. Delta frequency activity decreased with increasing GA (r = -0.8; P = .001 for infants with IUGR and r = -0.9; P < .001 for controls). The Lacey Assessment of the Preterm Infant developmental score was significantly lower in the infants with IUGR (P < .02) and was correlated with aEEG trace width (r = -0.6; P = .002) and with delta activity (r = -0.5; P = .02).

CONCLUSION:

Preterm infants with IUGR have delayed EEG maturation associated with delayed neuromotor development. The predictive value of these alterations regarding developmental deficits associated with IUGR remains undetermined, however.

Copyright © 2014 Mosby, Inc. All rights reserved.

PMID:

 

24485822

 

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