CBD and Epilepsy Seizures - A New Study

This is a study of a pharmaceutical grade pill going through FDA approval. This is NOT a study of nutritional CBD.

The study observed a 22% reduction in seizures. 5% were seizure free. This will be a welcome addition, to therapy.

I always remind parents to watch this literature AND to watch reports of side effects of the agent.

This agent is NOT available in Texas.  CBD is not available from a Texas source at this time. Tough situation for kids- JR


Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Orrin Devinsky, M.D., J. Helen Cross, Ph.D., F.R.C.P.C.H., Linda Laux, M.D., Eric Marsh, M.D., Ian Miller, M.D., Rima Nabbout, M.D., Ingrid E. Scheffer, M.B., B.S., Ph.D., Elizabeth A. Thiele, M.D., Ph.D., and Stephen Wright, M.D., for the Cannabidiol in Dravet Syndrome Study Group*

N Engl J Med 2017; 376:2011-2020May 25, 2017DOI: 10.1056/NEJMoa1611618

BACKGROUND

The Dravet syndrome is a complex childhood epilepsy disorder that is associated with drug-resistant seizures and a high mortality rate. We studied cannabidiol for the treatment of drug-resistant seizures in the Dravet syndrome.

CONCLUSIONS

Among patients with the Dravet syndrome, cannabidiol resulted in a greater reduction in convulsive-seizure frequency than placebo and was associated with higher rates of adverse events. 

Preview Article HERE

Dr. Rotenberg to speak at Houston Epilepsy Foundation Conference

  

2012 Family Conference

November 10, 2012

Toyota Center

Houston, Texas

Registration

2:00 p.m.

Session I

3:00 p.m.

Parent Track: Dr. Rotenberg- Seizures and Sleep

Adult Track: Maria Palacios- Living Well with Epilepsy

Session II

4:00 p.m.

Parent Track: Mary Jane Williams- IEP and ARD Overview

Adult Track: Dr. Hartshorn- Medical Management

Session III

5:00 p.m.

Parent Track: Dr. Wilfong- New Treatment & Surgery Options

 

Adult Track: Dr. Kalamagalam- 

New Treatment & Surgery Options

Dinner

6:00 p.m.

Houston Rockets vs. Detroit Pistons

7:00 p.m.

Activities will be provided for children 

ages 6-13 years during the conference

**Parking is not included in the ticket price. 

Participants are responsible for their own parking 

at the Toyota Center**

Contact Heather at hpena@eftx.org

buy tickets here 

or 888-548-9716 or 713-789-6295 with any questions. 

 link to full flyer here

Febrile seizures and behavioural and cognitive outcomes in preschool children: the Generation R Study

Are febrile seizures really totally benign? JR


Febrile seizures and behavioural and cognitive

 outcomes in preschool children: 

the Generation R Study

Aim 

 General developmental outcome is known to be good in school-aged children who experienced febrile seizures. We examined cognitive and behavioural outcomes in preschool children with febrile seizures, including language and executive functioning outcomes.

Method  This work was performed in the Generation R Study, a population-based cohort study in Rotterdam from early fetal life onwards. Information about the occurrence of febrile seizures was collected by questionnaires at the ages of 1, 2, and 3 years. At the age of 3 years, behaviour and emotion were assessed using the Child Behavior Checklist. Information on expressive language development was obtained by the Language Development Survey at the age of 2 years 6 months. To assess executive functioning, parents completed the Behaviour Rating Inventory of Executive Function – Preschool Version when their children were 4 years old. Final analyses were based on 3157 children.

Results  No associations were found between febrile seizures and the risk of behavioural problems or executive functioning. In contrast to single febrile seizures, recurrent febrile seizures were significantly associated with an increased risk of delayed vocabulary development (odds ratio 3.22, [95% confidence interval 1.30–7.94]).

Interpretation  Febrile seizures are not associated with problem behaviour or executive functioning in preschool children, but the results suggest that children with recurrent febrile seizures might be at risk for delayed language development.

 link here